{"id":"W3206441429","doi":"10.1001/jamanetworkopen.2021.28652","title":"Immunogenicity and Safety of a 3-Antigen Hepatitis B Vaccine vs a Single-Antigen Hepatitis B Vaccine","year":2021,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Sudbury; LMC Diabetes & Endocrinology (Canada); Manna Research","funders":"Universiteit Antwerpen; Novo Nordisk; National Institute for Health and Care Research; World Health Organization; Sanofi; Kowa Company; Gilead Sciences; Medpace; GlaxoSmithKline; Bill and Melinda Gates Foundation; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Reactogenicity; Hepatitis B virus; Vaccination; Immunogenicity; Hepatitis B; Randomized controlled trial; Internal medicine; Hepatitis B vaccine; Immunology; Antigen; HBsAg; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003710902,0.0003312524,0.0009080177,0.0001868545,0.0001604398,0.0004850834,0.0003426428,0.0009523096,0.002210917],"category_scores_gemma":[0.003496768,0.0001903785,0.0008991127,0.0001970397,0.0004475244,0.0006450742,0.0002496782,0.0008790407,0.0002680422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002917773,"about_ca_system_score_gemma":0.0006856237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002885239,"about_ca_topic_score_gemma":0.000271739,"domain_scores_codex":[0.9987963,0.0006874712,0.0001103042,0.000117375,0.0002206041,0.0000678885],"domain_scores_gemma":[0.9980177,0.0007493788,0.000719949,0.0001123105,0.0001550001,0.0002457071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8267263,0.01919778,0.01451715,0.001687943,0.002070718,0.0000733716,0.0002243454,0.001595751,0.02338389,0.0003794322,0.0006220666,0.1095213],"study_design_scores_gemma":[0.1528643,0.7931628,0.03996041,0.0003059926,0.001327755,0.0001617316,0.0001018612,0.002142205,0.007721156,0.0005831047,0.001639555,0.00002919021],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962102,0.002255611,0.0003399267,0.0001450619,0.00009299319,0.0003343175,0.000116521,0.00001151799,0.0004937475],"genre_scores_gemma":[0.9979761,0.0006695012,0.0004151513,0.0001606256,0.00007926891,0.0003200218,0.000115371,0.000003033806,0.00026106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003710902,"threshold_uncertainty_score":0.01962531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02214452000272129,"score_gpt":0.2741600049162082,"score_spread":0.2520154849134869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}