{"id":"W3206441429","doi":"10.1001/jamanetworkopen.2021.28652","title":"Immunogenicity and Safety of a 3-Antigen Hepatitis B Vaccine vs a Single-Antigen Hepatitis B Vaccine","year":2021,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Sudbury; LMC Diabetes & Endocrinology (Canada); Manna Research","funders":"Universiteit Antwerpen; Novo Nordisk; National Institute for Health and Care Research; World Health Organization; Sanofi; Kowa Company; Gilead Sciences; Medpace; GlaxoSmithKline; Bill and Melinda Gates Foundation; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Reactogenicity; Hepatitis B virus; Vaccination; Immunogenicity; Hepatitis B; Randomized controlled trial; Internal medicine; Hepatitis B vaccine; Immunology; Antigen; HBsAg; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001001354,0.0004707082,0.00173536,0.00009911558,0.0003862773,0.0001689351,0.0004544071,0.0002671393,0.001486521],"category_scores_gemma":[0.0007642059,0.0004515739,0.0002325625,0.0009330034,0.00008092677,0.0004095989,0.001733221,0.0004301814,0.00006253031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001771483,"about_ca_system_score_gemma":0.0003173223,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.0213391,"about_ca_topic_score_gemma":0.03391077,"domain_scores_codex":[0.9962562,0.0003803085,0.00124467,0.0008131556,0.0005087931,0.0007969089],"domain_scores_gemma":[0.9971153,0.000391201,0.0004522317,0.001031608,0.0007153518,0.0002942777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0014837,0.0002925291,0.9518497,0.0001532258,0.001113128,0.0004694063,0.0006008116,0.00002260137,0.002048035,0.0002936297,0.02500753,0.01666569],"study_design_scores_gemma":[0.005007958,0.0006552972,0.9252133,0.001185339,0.0002790994,0.0002516012,0.00004480886,0.0003827109,0.003910267,0.0002808863,0.06236739,0.0004213852],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686183,0.01395969,0.0003591242,0.006080931,0.0004161446,0.001534342,0.0001593018,0.00008569982,0.008786445],"genre_scores_gemma":[0.9426529,0.04495109,0.007617482,0.002248742,0.0006981818,0.00008074904,0.0002301604,0.00009464074,0.001426059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03735986,"threshold_uncertainty_score":0.9997936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02214452000272129,"score_gpt":0.2741600049162082,"score_spread":0.2520154849134869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}