{"id":"W3206649968","doi":"10.3390/v13102046","title":"African Swine Fever Virus A528R Inhibits TLR8 Mediated NF-κB Activity by Targeting p65 Activation and Nuclear Translocation","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"African swine fever virus; Chromosomal translocation; NF-κB; Virology; Biology; Innate immune system; Virus; Nuclear localization sequence; Phosphorylation; Immunity; Signal transduction; Gene; Immune system; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001164224,0.0002797785,0.000170333,0.0001076197,0.0001038428,0.0001200766,0.0001078896,0.0002275242,0.001540449],"category_scores_gemma":[0.00008012918,0.00006343532,0.0002201649,0.00005180435,0.0001330049,0.0001121914,0.00008819503,0.0003018176,0.0003238706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002715,"about_ca_system_score_gemma":0.0001337998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004056357,"about_ca_topic_score_gemma":0.0004969773,"domain_scores_codex":[0.9999157,0.00002133691,0.000008610818,0.00001148733,0.00001595557,0.00002686941],"domain_scores_gemma":[0.9999677,0.000005485426,0.00001027357,0.000004432057,0.000004187165,0.000007997714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723164,0.0001000193,0.0001680521,0.00004971624,0.000007739239,0.00002982833,0.000006844134,0.00004502153,0.9967113,0.00005542567,0.00007970403,0.002574146],"study_design_scores_gemma":[0.0001473997,0.003688851,0.00856316,0.00002759674,0.0000311372,0.0005386664,0.00004613485,0.002109205,0.9796565,0.00007812698,0.005105246,0.000007972038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924687,0.003609135,0.001481424,0.0001128381,0.00005598219,0.00002197311,0.00009612749,0.00005913732,0.002094649],"genre_scores_gemma":[0.9965258,0.0009991397,0.0008337877,0.00006010176,0.00001306261,0.00001801829,0.0001598597,0.000004967896,0.001385305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001540449,"threshold_uncertainty_score":0.005153298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02792239216544524,"score_gpt":0.229536573262044,"score_spread":0.2016141810965988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}