{"id":"W3206693972","doi":"10.1111/tid.13743","title":"Impact of immunosuppression on the immune response to SARS‐CoV‐2 infection: A mechanistic study","year":2021,"lang":"en","type":"article","venue":"Transplant Infectious Disease","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Tacrolimus; Immunosuppression; Immunology; Sirolimus; Cytokine; Immune system; Prednisone; Peripheral blood mononuclear cell; Mycophenolate; Mycophenolic acid; Proinflammatory cytokine; Cytokine storm; Coronavirus disease 2019 (COVID-19); Transplantation; Internal medicine; Inflammation; In vitro; Biology; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004260462,0.0003184273,0.0004075539,0.0001309176,0.000152127,0.0004665444,0.0001723737,0.0002424697,0.001381062],"category_scores_gemma":[0.0002036472,0.00007833407,0.0003786262,0.0001003331,0.0002668035,0.0003096389,0.0001760779,0.0003910858,0.0001793381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000129939,"about_ca_system_score_gemma":0.0001894233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007598414,"about_ca_topic_score_gemma":0.0001661308,"domain_scores_codex":[0.9998326,0.00007970142,0.0000120913,0.00001528364,0.0000205262,0.00003984203],"domain_scores_gemma":[0.999814,0.00005835222,0.00005790221,0.00001995261,0.0000131169,0.0000367124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01078396,0.00275042,0.06720604,0.0008825744,0.0003043096,0.002007334,0.000348763,0.000722541,0.8581886,0.0004787963,0.00023478,0.0560919],"study_design_scores_gemma":[0.00101076,0.07971572,0.6281572,0.0002923265,0.001057355,0.008719967,0.001067952,0.003640275,0.2642875,0.00059154,0.01142449,0.00003490244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964024,0.002930521,0.0001560645,0.00006026,0.00001116925,0.00002022658,0.00002496642,0.000002115723,0.0003923081],"genre_scores_gemma":[0.9971771,0.002097557,0.0002554697,0.0001053208,0.00007763741,0.00002088825,0.00007006113,0.000001337738,0.0001946581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381062,"threshold_uncertainty_score":0.004620135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03309372731384035,"score_gpt":0.3577486542373539,"score_spread":0.3246549269235136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}