{"id":"W3206693972","doi":"10.1111/tid.13743","title":"Impact of immunosuppression on the immune response to SARS‐CoV‐2 infection: A mechanistic study","year":2021,"lang":"en","type":"article","venue":"Transplant Infectious Disease","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Tacrolimus; Immunosuppression; Immunology; Sirolimus; Cytokine; Immune system; Prednisone; Peripheral blood mononuclear cell; Mycophenolate; Mycophenolic acid; Proinflammatory cytokine; Cytokine storm; Coronavirus disease 2019 (COVID-19); Transplantation; Internal medicine; Inflammation; In vitro; Biology; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000625327,0.0002863252,0.000421355,0.0002869123,0.0002302166,0.00004780505,0.0001451252,0.00007667878,0.0001199258],"category_scores_gemma":[0.0005740136,0.0001892984,0.0004344788,0.0007964071,0.00005880912,0.00005853681,0.00005077254,0.0003823587,0.0001509118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002170182,"about_ca_system_score_gemma":0.0008609396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008539418,"about_ca_topic_score_gemma":0.00006532251,"domain_scores_codex":[0.9975102,0.000643788,0.0004016594,0.0004219844,0.0006337772,0.0003885785],"domain_scores_gemma":[0.9980356,0.0005995525,0.00006997294,0.0009057511,0.0002634587,0.0001256918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03036571,0.005107369,0.1974313,0.0001822412,0.0005533787,0.001648703,0.001138951,0.00002803876,0.7627999,0.0001216715,0.0001561874,0.0004664789],"study_design_scores_gemma":[0.004348427,0.005555834,0.7670494,0.0005499533,0.000557813,0.0001830238,0.00007736221,0.0001229798,0.2201609,0.0001920395,0.0009181213,0.0002841203],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967544,0.0002123604,0.0002724117,0.0003725578,0.0001776873,0.001347478,0.0001276805,0.0001242083,0.000611179],"genre_scores_gemma":[0.9963889,0.00001526632,0.000002580084,0.003245314,0.00006528425,0.0001974513,0.00001351658,0.00004096503,0.00003069339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.569618,"threshold_uncertainty_score":0.7719364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03309372731384035,"score_gpt":0.3577486542373539,"score_spread":0.3246549269235136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}