{"id":"W3206757457","doi":"10.1371/journal.ppat.1009965","title":"Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Office of Science; Medicines for Malaria Venture; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Argonne National Laboratory; U.S. Department of Energy; McGill University Health Centre; McGill University; Canadian Institutes of Health Research; Association Vaincre la Mucoviscidose; University of Saskatchewan","keywords":"Mycobacterium abscessus; Norvaline; Microbiology; Clarithromycin; Mutant; Biology; Antibiotics; Mycobacterium; Amino acid; Leucine; Biochemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008078139,0.0002145002,0.0002316429,0.0001133474,0.00005299088,0.0001552359,0.0001566252,0.0001827653,0.0007209851],"category_scores_gemma":[0.0001332094,0.00006417152,0.0001624451,0.00004935727,0.0001208528,0.0001245182,0.0001538347,0.0003667909,0.0002002279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001003356,"about_ca_system_score_gemma":0.00009150927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001699756,"about_ca_topic_score_gemma":0.0002846731,"domain_scores_codex":[0.9999181,0.00001908573,0.000007436668,0.00001388574,0.00002182142,0.00001969105],"domain_scores_gemma":[0.9999073,0.00001785395,0.0000265506,0.000008077513,0.00001481768,0.00002539116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004770713,0.00006280137,0.0002022379,0.00004406782,0.000007790102,0.00003677491,0.000008609119,0.00008213057,0.9963034,0.00003078378,0.00003890307,0.002705289],"study_design_scores_gemma":[0.000028549,0.001749975,0.003242256,0.00000901477,0.00001685424,0.0001880707,0.00001330212,0.0006380175,0.9919962,0.000029585,0.002083312,0.000004862653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952703,0.002025561,0.0009821948,0.00008940844,0.00002658044,0.00001631432,0.0001220224,0.0000694794,0.001398133],"genre_scores_gemma":[0.9969971,0.0006210573,0.0007868158,0.00005502848,0.00001092345,0.00001087141,0.0002285708,0.0000122176,0.001277442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007209851,"threshold_uncertainty_score":0.002411902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055477322302259,"score_gpt":0.26573951058151,"score_spread":0.2451847373584874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}