{"id":"W3206757457","doi":"10.1371/journal.ppat.1009965","title":"Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Office of Science; Medicines for Malaria Venture; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Argonne National Laboratory; U.S. Department of Energy; McGill University Health Centre; McGill University; Canadian Institutes of Health Research; Association Vaincre la Mucoviscidose; University of Saskatchewan","keywords":"Mycobacterium abscessus; Norvaline; Microbiology; Clarithromycin; Mutant; Biology; Antibiotics; Mycobacterium; Amino acid; Leucine; Biochemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001412096,0.0002269161,0.0005520806,0.0001291327,0.00005922454,0.00002687794,0.0001216992,0.0001130154,0.001292115],"category_scores_gemma":[0.0005624496,0.0001810753,0.0001585508,0.0005587028,0.00009656049,0.00007322768,0.00006181883,0.0002315664,0.0001110148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004850972,"about_ca_system_score_gemma":0.0005458626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005046777,"about_ca_topic_score_gemma":0.00002477182,"domain_scores_codex":[0.9980101,0.00009188373,0.0003530692,0.0004336053,0.0006463153,0.0004650498],"domain_scores_gemma":[0.9978042,0.0002383695,0.0001112914,0.0007045623,0.0006641604,0.0004774056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009864706,0.001582242,0.2209369,0.0004434714,0.0003178348,0.001393267,0.000220394,0.000001388916,0.7719517,0.0000192526,0.0008648231,0.001282221],"study_design_scores_gemma":[0.004041056,0.0005502056,0.3965977,0.0003917986,0.0003053291,0.0000607142,0.0001017757,0.00007419995,0.5943984,0.000004881772,0.003264592,0.0002093883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990037,0.0003773283,0.00001531046,0.0008631144,0.00004782349,0.0003376552,0.0005184367,0.00006777338,0.007735518],"genre_scores_gemma":[0.9958126,0.0004655492,0.001544379,0.001018959,0.0002482869,0.00003898477,0.0004708585,0.00004976484,0.0003506367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1775534,"threshold_uncertainty_score":0.9996209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055477322302259,"score_gpt":0.26573951058151,"score_spread":0.2451847373584874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}