{"id":"W3206790308","doi":"10.3390/cancers13205039","title":"Enhancing Therapeutic Efficacy of Double Negative T Cells against Acute Myeloid Leukemia Using Idelalisib","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Cancer Society; Leukemia and Lymphoma Society","keywords":"Idelalisib; Myeloid leukemia; Cancer research; Haematopoiesis; Transplantation; Myeloid; Hematopoietic stem cell transplantation; Leukemia; Medicine; Stem cell; Chemistry; Immunology; Biology; Internal medicine; Cell biology; Ibrutinib; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463203,0.0003139823,0.0002758921,0.0002332704,0.0001027971,0.0003109791,0.0001618852,0.0001897934,0.0006907581],"category_scores_gemma":[0.0000967824,0.00006740519,0.0001399918,0.0001112038,0.0001481506,0.0001925904,0.000145648,0.0005797192,0.0001826275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001889824,"about_ca_system_score_gemma":0.000218079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001473775,"about_ca_topic_score_gemma":0.0003553617,"domain_scores_codex":[0.9999057,0.00001825132,0.000007540628,0.00001581972,0.00001846541,0.00003424346],"domain_scores_gemma":[0.9999647,0.0000053221,0.00001054068,0.000003807951,0.000003000152,0.00001274165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001175602,0.0007363314,0.0007385833,0.0001380355,0.00002275318,0.000108079,0.00004491136,0.0009276933,0.9568227,0.0005717154,0.0006204883,0.03809312],"study_design_scores_gemma":[0.0005579172,0.01320907,0.004545446,0.00002169846,0.00008928114,0.0009609916,0.00004362874,0.004999185,0.9645349,0.0002051551,0.010819,0.00001381653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994121,0.001474088,0.00184572,0.00009499248,0.00004533867,0.00006203288,0.000154581,0.00007545855,0.002126788],"genre_scores_gemma":[0.9973487,0.0006173858,0.0009725703,0.00004926523,0.00001377035,0.00004883045,0.0001909796,0.000006502127,0.0007519391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006907581,"threshold_uncertainty_score":0.002310812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04518843191315285,"score_gpt":0.3454976100233685,"score_spread":0.3003091781102156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}