{"id":"W3206814635","doi":"10.1017/s1092852921000936","title":"Vortioxetine 20 mg/day in patients with major depressive disorder: updated analysis of efficacy, safety, and optimal timing of dose adjustment","year":2021,"lang":"en","type":"article","venue":"CNS Spectrums","topic":"Treatment of Major Depression","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Allergan; Bausch Health; H. Lundbeck A/S; Pfizer; Vifor Pharma; Italfarmaco; Eisai; Purdue University; Canadian Institutes of Health Research; Sunovion; Novo Nordisk; Daiichi Sankyo Europe; Sanofi; Mylan","keywords":"Vortioxetine; Tolerability; Placebo; Major depressive disorder; Medicine; Adverse effect; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00627881,0.0007236548,0.003790739,0.0009983045,0.0001399014,0.001016982,0.0005438207,0.0004773439,0.0008755161],"category_scores_gemma":[0.007815156,0.0005709656,0.005389046,0.000983722,0.0001870321,0.0005478747,0.0003816312,0.0006535327,0.00009304243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007507331,"about_ca_system_score_gemma":0.0008193931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001329762,"about_ca_topic_score_gemma":0.003458853,"domain_scores_codex":[0.9966956,0.001875538,0.0005695776,0.000384125,0.0003709814,0.000104156],"domain_scores_gemma":[0.9939941,0.001961743,0.003136481,0.0003056378,0.0004626384,0.0001395068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2337397,0.0007941412,0.1127108,0.02340676,0.2889706,0.0003612644,0.0001483913,0.005101055,0.01328504,0.0002146439,0.003348422,0.3179193],"study_design_scores_gemma":[0.08875366,0.03172456,0.5789388,0.001997028,0.2798654,0.0008655729,0.00008794745,0.0044048,0.003104669,0.0004754129,0.00963515,0.0001470171],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.602886,0.3885117,0.002398749,0.0006619572,0.000207547,0.0005620389,0.00309712,0.0001380896,0.001536788],"genre_scores_gemma":[0.968914,0.02602673,0.002076946,0.0004397191,0.0002230027,0.0002355095,0.001837226,0.00001839807,0.0002285073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00627881,"threshold_uncertainty_score":0.03320593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00624271703568284,"score_gpt":0.2404998107073598,"score_spread":0.234257093671677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}