{"id":"W3206830763","doi":"10.1002/dad2.12242","title":"The global Alzheimer's Association round robin study on plasma amyloid β methods","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Engineering and Physical Sciences Research Council; National Institutes of Health; UK Dementia Research Institute; Marcus och Amalia Wallenbergs minnesfond; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Eisai; Hjärnfonden; Familjen Erling-Perssons Stiftelse; European Commission; University College London; British Heart Foundation; National Institute on Aging; National Institute for Health and Care Research; National Center for Geriatrics and Gerontology; Celgene; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Centene Corporation; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Drug Discovery Foundation; ZonMw; Weston Brain Institute; Lunds Universitet; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Alzheimer Nederland; Biogen; University of Pennsylvania; Japan Agency for Medical Research and Development; BrightFocus Foundation; Eli Lilly and Company; Australian Government; Cure Alzheimer's Fund","keywords":"Cerebrospinal fluid; Alzheimer's disease; Measure (data warehouse); Blood plasma; Amyloid beta; Amyloid (mycology); Antibody; Chemistry; Medicine; Pathology; Internal medicine; Immunology; Psychology; Disease; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001305214,0.0007511972,0.0007375208,0.0001285183,0.001383213,0.0008181015,0.0004464089,0.0001521342,0.0001975058],"category_scores_gemma":[0.0003700328,0.0006147062,0.0006275433,0.0008663584,0.00008984188,0.0004545013,0.0004610743,0.0005543451,0.0001916388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008597865,"about_ca_system_score_gemma":0.001159194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001678278,"about_ca_topic_score_gemma":0.00002588278,"domain_scores_codex":[0.992344,0.001476859,0.0009109524,0.001324534,0.002531235,0.001412458],"domain_scores_gemma":[0.9946374,0.001361633,0.0004303437,0.001431662,0.0006627087,0.001476262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002933458,0.006419202,0.8174871,0.00001080117,0.1483245,0.0007477223,0.00004937519,0.00003817468,0.00002511251,0.0001921949,0.001343475,0.025069],"study_design_scores_gemma":[0.004021471,0.0006674018,0.9218158,0.0001665386,0.06262855,0.000005130761,0.001062381,0.0001600925,0.005437171,0.0002605693,0.003233379,0.000541563],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7830255,0.2035777,0.00009836747,0.004126839,0.002957869,0.003832409,0.000223754,0.0003730757,0.001784445],"genre_scores_gemma":[0.9911323,0.002197049,0.002292361,0.000178982,0.0008326377,0.003035085,0.0002061132,0.0001037967,0.0000216461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2081068,"threshold_uncertainty_score":0.9999169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06142174961877225,"score_gpt":0.420980907320619,"score_spread":0.3595591577018468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}