{"id":"W3206837711","doi":"10.1001/jamaneurol.2021.3671","title":"Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum","year":2021,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":631,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Wallenberg Centre for Molecular and Translational Medicine; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable; Université de Paris; King's College London; Göteborgs Universitet; Institut National de la Santé et de la Recherche Médicale; Sahlgrenska Akademin; Universitat Pompeu Fabra; Assistance Publique - Hôpitaux de Paris; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Cerebrospinal fluid; Glial fibrillary acidic protein; Alzheimer's disease; Pathology; Disease; Medicine; Neuroscience; Psychology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006933385,0.0003232746,0.0003292299,0.00110277,0.0005405894,0.0007882508,0.0003333052,0.0004363997,0.0006111527],"category_scores_gemma":[0.002075747,0.0002162721,0.0002728548,0.001085593,0.0003612405,0.0005089828,0.0005076862,0.0003930327,0.0002021476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003509127,"about_ca_system_score_gemma":0.0002688573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006062813,"about_ca_topic_score_gemma":0.006133806,"domain_scores_codex":[0.9993986,0.0001310597,0.00006566872,0.0001970829,0.0001241033,0.00008352947],"domain_scores_gemma":[0.9988229,0.0001477268,0.000560296,0.00006911599,0.0002066146,0.0001933746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003766707,0.00004468906,0.9972691,0.000009418061,0.00006781159,0.00008997296,0.000146575,0.00003135551,0.0008557087,0.0000184782,0.00008501457,0.001005155],"study_design_scores_gemma":[0.000007458467,0.00008622242,0.9993435,0.000003281501,0.00001684358,0.000143997,0.0001092702,0.00005682949,0.0001251967,0.00003375659,0.00007080325,0.000002870738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987512,0.0001936146,0.0001154283,0.00002018823,0.000004188229,0.000009595879,0.0005916289,0.000005515908,0.0003085707],"genre_scores_gemma":[0.9988326,0.00007219276,0.0001752797,0.00002206392,0.000007423998,0.00002170373,0.0007309416,0.000002703081,0.0001349818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006062813,"threshold_uncertainty_score":0.01205504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03786129920125956,"score_gpt":0.3186401071832221,"score_spread":0.2807788079819625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}