{"id":"W3206903342","doi":"10.1126/sciadv.abj4565","title":"Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Ruler; Membrane; Integral membrane protein; Mechanism (biology); Chemistry; Biophysics; Stereochemistry; Biochemistry; Biology; Membrane protein; Physics; Quantum mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041444,0.0000681155,0.00007724196,0.00003574506,0.0001030083,0.00002929584,0.0002896428,0.00003043321,0.00002810798],"category_scores_gemma":[0.0002109279,0.00004692545,0.00004529876,0.0003614413,0.0004902891,0.00001722572,0.0001901668,0.00006336582,0.000001458736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005711735,"about_ca_system_score_gemma":0.0001499701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000186522,"about_ca_topic_score_gemma":0.0000808429,"domain_scores_codex":[0.999183,0.00003677901,0.0001062299,0.0002766713,0.0002383903,0.000158902],"domain_scores_gemma":[0.9994561,0.000005171066,0.0000270734,0.0002901268,0.0001666205,0.00005490203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001268665,0.00001589616,0.0002337298,0.00000969027,0.000005050242,0.000002095843,0.00004346482,0.00002820541,0.9916686,0.0008098959,0.000002152554,0.007168537],"study_design_scores_gemma":[0.0001470131,0.00004327738,0.0002447288,0.00001022253,0.000004601146,0.000009213239,0.0001613658,0.00006071308,0.9969766,0.0007018917,0.001580884,0.00005953134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960321,0.0007471308,0.002247087,0.0003489735,0.00008887014,0.00008261651,0.00001237485,0.000002648324,0.0004382261],"genre_scores_gemma":[0.9990676,0.0001124654,0.0004867266,0.0001234354,0.00001263757,0.000006320229,0.000009175355,0.000003713966,0.0001779441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007109005,"threshold_uncertainty_score":0.1913564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007376913788853854,"score_gpt":0.2751555749645959,"score_spread":0.2677786611757421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}