{"id":"W3206903342","doi":"10.1126/sciadv.abj4565","title":"Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Ruler; Membrane; Integral membrane protein; Mechanism (biology); Chemistry; Biophysics; Stereochemistry; Biochemistry; Biology; Membrane protein; Physics; Quantum mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003395288,0.0003485174,0.0002584594,0.0001508953,0.0002505981,0.0005286051,0.0003954752,0.0004864003,0.0005277703],"category_scores_gemma":[0.0004771122,0.000166866,0.0002418885,0.00008158489,0.0005440335,0.0006965608,0.000378598,0.0009085719,0.0003361069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973546,"about_ca_system_score_gemma":0.0001760186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002379717,"about_ca_topic_score_gemma":0.0001755384,"domain_scores_codex":[0.9998482,0.00002548617,0.000009207743,0.00003951932,0.00005520306,0.00002235017],"domain_scores_gemma":[0.9998102,0.00007477341,0.00004432777,0.00002705968,0.00001998812,0.00002362248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005810308,0.00002619131,0.0003413478,0.00006020311,0.000009732519,0.0001958906,0.00004380312,0.0003917358,0.9934832,0.002908556,0.0000465792,0.002434598],"study_design_scores_gemma":[0.00001364546,0.00007989009,0.0005189058,0.000003682175,0.00001027313,0.000430657,0.00002479654,0.008991202,0.987947,0.0008045966,0.00116662,0.000008713982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504595,0.001837105,0.04406578,0.0005778183,0.00007769876,0.00006003271,0.0000816159,0.0001872555,0.002653267],"genre_scores_gemma":[0.9916508,0.0005291696,0.007014937,0.00006868904,0.00001393978,0.00002538036,0.00006849405,0.00001247426,0.0006161446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005286051,"threshold_uncertainty_score":0.00215745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007376913788853854,"score_gpt":0.2751555749645959,"score_spread":0.2677786611757421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}