{"id":"W3206966399","doi":"10.21203/rs.3.rs-686543/v1","title":"Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Reumatikerförbundet; Vetenskapsrådet; McGill University; Hjärt-Lungfonden; Ulla och Gustaf af Ugglas Stiftelse; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Karolinska Institutet; European Commission; Myositis Association; European Federation of Pharmaceutical Industries and Associations","keywords":"Autoantibody; Myositis; Cohort; splice; Medicine; Genetics; Immunology; Internal medicine; Antibody; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004376946,0.0003939254,0.0003603759,0.0008401265,0.0006961262,0.0007959616,0.0003260181,0.000652269,0.001102101],"category_scores_gemma":[0.001428643,0.0002901199,0.0003493257,0.0005460649,0.0003051929,0.0006570388,0.0004446096,0.000689599,0.0004492572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00023515,"about_ca_system_score_gemma":0.0001943419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002477445,"about_ca_topic_score_gemma":0.001249401,"domain_scores_codex":[0.9996718,0.00006332267,0.00002806675,0.0001155768,0.0000503606,0.00007075543],"domain_scores_gemma":[0.9990624,0.0001448454,0.0003271335,0.00007219979,0.0001400849,0.0002534259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003437507,0.0001266108,0.9948579,0.000003381614,0.00003141713,0.0005045097,0.0002080081,0.00003056335,0.002640995,0.00001954248,0.00005661726,0.001176817],"study_design_scores_gemma":[0.000005277721,0.0002603677,0.9980598,0.000001808335,0.00001832647,0.0009774794,0.0002469668,0.0001032587,0.0001714942,0.00001924888,0.0001312798,0.000004700948],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996616,0.00004360638,0.00003720629,0.00001565935,0.000003084649,0.000002368543,0.00006740518,0.000002226324,0.0001668203],"genre_scores_gemma":[0.9993874,0.00003338075,0.00003725875,0.00001906975,0.00000647387,0.000004009782,0.0001875521,0.00000205601,0.0003228305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002477445,"threshold_uncertainty_score":0.004926085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242565162201259,"score_gpt":0.3401332243981893,"score_spread":0.3177075727761767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}