{"id":"W3206978851","doi":"10.1186/s13039-021-00567-w","title":"Differentially accessible, single copy sequences form contiguous domains along metaphase chromosomes that are conserved among multiple tissues","year":2021,"lang":"en","type":"article","venue":"Molecular Cytogenetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cytodiagnostics (Canada); Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario","keywords":"Biology; Metaphase; Chromatin; Fluorescence in situ hybridization; Genetics; Premature chromosome condensation; Chromosome; Homologous chromosome; Cytogenetics; Molecular biology; Prophase; Mitosis; DNA; Gene; Meiosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001265241,0.0004673756,0.0004896377,0.0000709055,0.0002131476,0.0002781784,0.0005247424,0.0003456635,0.00005249444],"category_scores_gemma":[0.000141037,0.0004856322,0.0003136051,0.0001892013,0.0002773936,0.00001126432,0.0004312831,0.000149924,0.000008705332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004697339,"about_ca_system_score_gemma":0.0001985825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007181736,"about_ca_topic_score_gemma":0.00165271,"domain_scores_codex":[0.9976128,0.0001570489,0.0004837383,0.000785875,0.000365387,0.0005951464],"domain_scores_gemma":[0.998194,0.00002927853,0.0003351644,0.0008915049,0.0003055699,0.0002444847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002975835,0.0002101791,0.2011983,0.00005511757,0.0003334846,0.0004103266,0.00006059019,0.0003219172,0.7966756,0.00003824964,0.0001296944,0.0005367584],"study_design_scores_gemma":[0.001426659,0.0002173712,0.01423215,0.00005438839,0.0001797526,0.00009117282,0.00028959,0.000398961,0.9800916,0.0002896321,0.002115166,0.0006135178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981819,0.005167895,0.01162912,0.0001178335,0.0002981088,0.0003483173,0.0001969661,0.00004317539,0.0003795258],"genre_scores_gemma":[0.9903491,0.0007682324,0.007029384,0.0003582325,0.000107511,0.00004597095,0.0008818815,0.00009790388,0.000361749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1869662,"threshold_uncertainty_score":0.9997596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01917276466577714,"score_gpt":0.2454967930479383,"score_spread":0.2263240283821612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}