{"id":"W3206996158","doi":"10.1016/j.cell.2021.09.022","title":"Spatially confined sub-tumor microenvironments in pancreatic cancer","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":423,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Occupational Cancer Research Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Biology; Tumor microenvironment; Pancreatic cancer; Phenotype; Fibroblast; Cancer research; Tumor progression; Genetic heterogeneity; Immune system; Cancer-Associated Fibroblasts; Pancreatic tumor; Cancer; Immunology; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116019,0.0001035641,0.0001915772,0.0003365164,0.0004753458,0.0009314313,0.0002006673,0.0002528016,0.00126051],"category_scores_gemma":[0.0001478118,0.0001662939,0.0001056229,0.0003053955,0.0004432922,0.0006123902,0.0005412558,0.0003651788,0.0002327822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006061008,"about_ca_system_score_gemma":0.0003453507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001797984,"about_ca_topic_score_gemma":0.002565457,"domain_scores_codex":[0.9999001,0.00002057362,0.000003962544,0.00002524206,0.00002381657,0.00002627955],"domain_scores_gemma":[0.999913,0.00001756568,0.00002348827,0.0000110567,0.00001037256,0.00002449658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009518604,0.0001135902,0.00956316,0.0003844369,0.00003923929,0.001197054,0.0007682313,0.002375041,0.9601502,0.007172644,0.0007231059,0.01656132],"study_design_scores_gemma":[0.0001307742,0.0007056035,0.1865774,0.00006837597,0.0001540143,0.00717671,0.006854141,0.008342237,0.7337849,0.005441887,0.05069232,0.00007167667],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827493,0.008968135,0.003292499,0.0003630266,0.00002718802,0.00001086964,0.0001237961,0.00005635526,0.004408848],"genre_scores_gemma":[0.9972064,0.001086566,0.0006470776,0.00004575856,0.00001240903,0.000009945872,0.00004451266,0.000005310331,0.0009420021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001797984,"threshold_uncertainty_score":0.004397631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02185218738619339,"score_gpt":0.3013799435676659,"score_spread":0.2795277561814725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}