{"id":"W3207033670","doi":"10.3390/microorganisms9102157","title":"The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin E. coli Mediated HUS","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"European Rare Kidney Disease Reference Network; Hospital for Sick Children","keywords":"Globotriaosylceramide; Glycosphingolipid; Shiga toxin; Biology; Microbiology; Vero cell; Endothelial stem cell; Cell; Toxin; Receptor; Molecular biology; Biochemistry; Escherichia coli; In vitro; Fabry disease; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0007965954,0.0003734505,0.0005836207,0.000144157,0.000313705,0.000193599,0.0005184166,0.0003379686,0.005171285],"category_scores_gemma":[0.001203322,0.0002905264,0.000178163,0.001477122,0.0002696506,0.0001159752,0.0002644092,0.0008448511,0.002443786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005751824,"about_ca_system_score_gemma":0.001176753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003411338,"about_ca_topic_score_gemma":0.0007150795,"domain_scores_codex":[0.9963557,0.0004469723,0.0006293528,0.0006973385,0.0008346026,0.001036001],"domain_scores_gemma":[0.9979107,0.0004923536,0.0001096317,0.0008350107,0.0003217087,0.000330545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005175199,0.0004730423,0.005116298,0.00005359444,0.0001742947,0.0005936559,0.001006003,0.000004072979,0.9785194,0.0004370496,0.009865463,0.003239558],"study_design_scores_gemma":[0.005178879,0.0004144988,0.01622257,0.0001120966,0.00005406822,0.0001734876,0.002396543,0.00006174995,0.7846534,0.001558847,0.188703,0.0004708362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9584619,0.01070311,0.00008998488,0.02326649,0.0006140639,0.001179141,0.0000461264,0.0001777804,0.005461422],"genre_scores_gemma":[0.9758804,0.001344448,0.0008969196,0.005981486,0.0002881305,0.00009658701,0.0002639358,0.0001532562,0.0150948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.193866,"threshold_uncertainty_score":0.9999547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01733561998537413,"score_gpt":0.2857008018668934,"score_spread":0.2683651818815193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}