{"id":"W3207074037","doi":"10.1080/17425255.2021.1992382","title":"Antisense oligonucleotides: absorption, distribution, metabolism, and excretion","year":2021,"lang":"en","type":"review","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Ottawa","funders":"Sarepta Therapeutics","keywords":"ADME; Pharmacokinetics; Pharmacology; Morpholino; Chemistry; Oligonucleotide; Biochemistry; Medicine; Gene knockdown; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007079286,0.000498682,0.0005288447,0.0002515955,0.00009159089,0.000773239,0.0001973556,0.0006875736,0.002381619],"category_scores_gemma":[0.001022001,0.0001469819,0.0004359128,0.0001691896,0.0003460188,0.0005410317,0.0001838037,0.0008230999,0.0008036141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005772557,"about_ca_system_score_gemma":0.0004765994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008082496,"about_ca_topic_score_gemma":0.0006329981,"domain_scores_codex":[0.999441,0.0001247821,0.00004229469,0.0001358378,0.0002144537,0.00004158667],"domain_scores_gemma":[0.9994086,0.0002048305,0.0002055536,0.00001767617,0.0001395135,0.0000239134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008340298,0.00008341638,0.003766146,0.007294135,0.0002054127,0.0009589102,0.0002146331,0.002779688,0.5019494,0.005956064,0.01497162,0.4609866],"study_design_scores_gemma":[0.0001286132,0.004446202,0.01536418,0.001227945,0.000613382,0.01510338,0.0002352572,0.006908532,0.5031393,0.005888416,0.4468055,0.0001393434],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1175249,0.7818973,0.06472196,0.007903644,0.002152489,0.000276451,0.001578573,0.0009094605,0.02303519],"genre_scores_gemma":[0.6551369,0.304566,0.01744219,0.003349996,0.001638675,0.0002664497,0.000981038,0.0001526866,0.01646603],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002381619,"threshold_uncertainty_score":0.007967293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02118673668677091,"score_gpt":0.3170868780850322,"score_spread":0.2959001413982613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}