{"id":"W3207129859","doi":"10.1016/j.immuni.2021.10.006","title":"Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring","year":2021,"lang":"en","type":"article","venue":"Immunity","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Università degli Studi di Torino; Fondazione Antonio Carlo Monzino; Ministero dell’Istruzione, dell’Università e della Ricerca; Ferring Pharmaceuticals; Ministero della Salute; Fondazione Cariplo; Fondazione Italiana Sclerosi Multipla; Fondazione Telethon; Associazione Italiana Sclerosi Multipla; Fondazione Pisa; Fondazione Cassa di Risparmio di Pisa","keywords":"Glutamatergic; Synaptogenesis; Offspring; Biology; Neuroscience; Synapse; Hippocampal formation; Pregnancy; Glutamate receptor; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002720366,0.0001400754,0.0001656529,0.0001049811,0.0001996159,0.0001199785,0.0001166317,0.00005313997,0.00006450227],"category_scores_gemma":[0.00179652,0.000150331,0.00003244633,0.0002742305,0.00006108227,0.0004110953,0.00022468,0.0002622548,0.00001930768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004483476,"about_ca_system_score_gemma":0.00005483268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001192594,"about_ca_topic_score_gemma":0.0004015124,"domain_scores_codex":[0.9982673,0.0007585051,0.0002517466,0.0003524896,0.0001773423,0.0001926377],"domain_scores_gemma":[0.9991177,0.0003650792,0.00009021055,0.0003059462,0.00004870868,0.00007239813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004782775,0.0001150472,0.004241327,0.00003088712,0.000001362211,0.0001349093,0.0001811018,0.00003096626,0.9909011,0.0036426,0.000003297839,0.0006696465],"study_design_scores_gemma":[0.0004900807,0.00003104958,0.0697272,0.00003648731,0.000003761772,0.0001909204,0.00005841873,0.001869915,0.9264696,0.0009754149,0.00001491327,0.0001321854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989375,0.00001573738,0.0003250015,0.0001703942,0.0001668925,0.0001519776,0.00001016109,0.00009655809,0.0001257741],"genre_scores_gemma":[0.9993371,0.00003603798,0.0000661729,0.0004428382,0.00002140926,0.000011231,0.00001028158,0.00001248436,0.00006249179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06548588,"threshold_uncertainty_score":0.6130319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312116731144103,"score_gpt":0.2561804486729365,"score_spread":0.2330592813614955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}