{"id":"W3207164227","doi":"10.1016/j.jmb.2021.167300","title":"A Panel of Engineered Ubiquitin Variants Targeting the Family of Domains Found in Ubiquitin Specific Proteases (DUSPs)","year":2021,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research; Ontario Research Foundation","keywords":"Proteases; Ubiquitin; Biology; Protease; Cell biology; Phage display; Genetics; Computational biology; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003373379,0.0006719655,0.0003390554,0.0003225952,0.000194825,0.0002840447,0.000403778,0.0005102438,0.001423802],"category_scores_gemma":[0.0002629737,0.0001907708,0.0003336698,0.0005011062,0.0002221233,0.0001515839,0.0002168252,0.0006446835,0.0003147544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004120405,"about_ca_system_score_gemma":0.000162624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009976602,"about_ca_topic_score_gemma":0.0015472,"domain_scores_codex":[0.9996397,0.00006839298,0.00005897693,0.00008354747,0.00007311365,0.00007608977],"domain_scores_gemma":[0.9997914,0.00005367669,0.0000407914,0.00003249312,0.00003170445,0.00004995694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003963568,0.0001108037,0.0004693993,0.00003533714,0.00003193599,0.0001278138,0.00001287562,0.0004171497,0.9967543,0.0001323194,0.0001210396,0.001390634],"study_design_scores_gemma":[0.00003878948,0.0004143483,0.001668097,0.000004655983,0.00004662588,0.0005123663,0.0000212873,0.0008379635,0.9942152,0.0000385561,0.002193486,0.000008740439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932007,0.0007229503,0.003892442,0.00007584909,0.00005902279,0.00005484555,0.001096576,0.00005998086,0.0008375728],"genre_scores_gemma":[0.9899716,0.0004967226,0.005484832,0.0001132324,0.000008214727,0.00005045624,0.00225917,0.0000384565,0.001577204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001423802,"threshold_uncertainty_score":0.004763126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02190278881776323,"score_gpt":0.2612426097284175,"score_spread":0.2393398209106542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}