{"id":"W3207226644","doi":"10.26508/lsa.202101054","title":"Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival","year":2021,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; European Regional Development Fund; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; European Commission; Fundacja na rzecz Nauki Polskiej; University of Edinburgh; Hashemite University; Cancer Research UK","keywords":"Bruton's tyrosine kinase; Ex vivo; Cancer research; SOX2; Tyrosine kinase; Biology; In vivo; Cell culture; Population; Medicine; Signal transduction; Cell biology; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003542266,0.0002591459,0.0003794652,0.0009084939,0.0002743963,0.0006210112,0.0001475173,0.0003201285,0.003366304],"category_scores_gemma":[0.0005218957,0.00009557664,0.0002489312,0.0006221383,0.0001675791,0.0003574031,0.0004105551,0.0004746228,0.0006699644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003360158,"about_ca_system_score_gemma":0.0002773003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00146201,"about_ca_topic_score_gemma":0.003062961,"domain_scores_codex":[0.9998055,0.00002532503,0.00001466974,0.00005838034,0.00005564601,0.00004046943],"domain_scores_gemma":[0.9996744,0.00004633743,0.0001374346,0.00002309888,0.0000582118,0.00006058302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002711965,0.0002994646,0.630887,0.0002803348,0.0004043902,0.0008233816,0.0002743471,0.001139484,0.3175569,0.0003689336,0.002558067,0.0426957],"study_design_scores_gemma":[0.00003028933,0.0005072313,0.9302914,0.00002667201,0.0002190729,0.002971871,0.0003871817,0.004147158,0.05689765,0.000604417,0.003882744,0.0000344216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932044,0.0007403747,0.002297988,0.0001962709,0.00002521686,0.00002292753,0.00210188,0.0001163459,0.001294688],"genre_scores_gemma":[0.9962149,0.0002575759,0.001136107,0.00007175082,0.000009431786,0.00002144266,0.001332092,0.000009297417,0.0009474808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003366304,"threshold_uncertainty_score":0.01126134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05197464540765671,"score_gpt":0.3371635521904023,"score_spread":0.2851889067827456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}