{"id":"W3207287416","doi":"10.1158/1078-0432.ccr-21-0158","title":"Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"AstraZeneca","keywords":"Carboplatin; Chemotherapy; Toxicity; Phases of clinical research; Combination chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001377135,0.0009376554,0.002090916,0.000475662,0.0003074686,0.0007566563,0.0007122305,0.0008257182,0.002516933],"category_scores_gemma":[0.0009650117,0.0005454656,0.00117311,0.0004433818,0.000660977,0.000894848,0.0003063879,0.002038156,0.0004497002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006740579,"about_ca_system_score_gemma":0.001152241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000569793,"about_ca_topic_score_gemma":0.001740598,"domain_scores_codex":[0.9994859,0.0002547949,0.00004270744,0.00008461154,0.00005953819,0.00007245973],"domain_scores_gemma":[0.9992554,0.0001242,0.0002296191,0.00006867393,0.0000506536,0.0002714693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6392008,0.1405549,0.01920283,0.001447046,0.00210656,0.0002225363,0.0002783553,0.001989074,0.05084766,0.00009987692,0.001499509,0.1425508],"study_design_scores_gemma":[0.3430711,0.633523,0.01607439,0.00003182562,0.0005373427,0.0002298185,0.00005582487,0.0009919581,0.003553241,0.00006962295,0.001837309,0.00002458855],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970713,0.001257288,0.0001745011,0.000122075,0.0000547453,0.000751258,0.0001874918,0.00003110408,0.0003501144],"genre_scores_gemma":[0.9948242,0.001289979,0.001037447,0.0003441692,0.0001477719,0.0008589834,0.0005080311,0.0000112851,0.0009781126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002516933,"threshold_uncertainty_score":0.008419931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.247773716913073,"score_gpt":0.5161284923830547,"score_spread":0.2683547754699817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}