{"id":"W3207287416","doi":"10.1158/1078-0432.ccr-21-0158","title":"Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"AstraZeneca","keywords":"Carboplatin; Chemotherapy; Toxicity; Phases of clinical research; Combination chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001535132,0.0004187769,0.001257507,0.0001725246,0.0004186869,0.000213678,0.0005649185,0.0001967633,0.002343171],"category_scores_gemma":[0.0001881494,0.0002697536,0.00005001762,0.001391606,0.0003646898,0.0003322559,0.0004180454,0.001228719,0.0000078806],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001205893,"about_ca_system_score_gemma":0.006286513,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005608584,"about_ca_topic_score_gemma":0.03526408,"domain_scores_codex":[0.9939768,0.0007484853,0.0009836869,0.00157988,0.001731008,0.000980181],"domain_scores_gemma":[0.9961293,0.0005549563,0.0001734092,0.001245901,0.001128615,0.0007678404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09804856,0.07239356,0.7175564,0.0001370424,0.0008830558,0.001962785,0.0007494324,0.000008527328,0.0000712174,0.00003625921,0.001836094,0.106317],"study_design_scores_gemma":[0.1331785,0.1002681,0.7538819,0.000852248,0.0001757039,0.000006170088,0.0004246579,0.00004273045,0.0001696403,0.0000132792,0.01061336,0.0003736462],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866071,0.0005617847,0.000002716018,0.007190701,0.0001750891,0.00426499,0.0001828839,0.00004128508,0.0009733993],"genre_scores_gemma":[0.9911413,0.0009945056,0.001161299,0.002027743,0.0004551705,0.002192685,0.0001416599,0.0001338727,0.001751787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1059434,"threshold_uncertainty_score":0.9999754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.247773716913073,"score_gpt":0.5161284923830547,"score_spread":0.2683547754699817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}