{"id":"W3207329022","doi":"10.1016/j.chembiol.2021.10.001","title":"SUMO wrestling cancer stem cells","year":2021,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"SUMO protein; Stem cell; Cancer cell; Cancer stem cell; Cell biology; Biology; Cell; Cancer; Cancer research; Posttranslational modification; Enzyme; Computational biology; Genetics; Biochemistry; Gene; Ubiquitin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869666,0.0002503844,0.0002767428,0.0003370262,0.0003044899,0.0008206586,0.0002161934,0.0003862848,0.003830261],"category_scores_gemma":[0.0001308889,0.0001859293,0.0002920862,0.0002265346,0.0002205489,0.0004216083,0.0003807324,0.0008262883,0.0008456639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002820717,"about_ca_system_score_gemma":0.0002520062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000464654,"about_ca_topic_score_gemma":0.001238492,"domain_scores_codex":[0.9998742,0.00001127386,0.00001078905,0.00002649094,0.00004839093,0.00002874739],"domain_scores_gemma":[0.9998928,0.00001537992,0.00002480534,0.00002128726,0.00001591284,0.00002969232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006799,0.00004092489,0.0004842516,0.00005680796,0.00001751427,0.0002259032,0.00004738631,0.0002090754,0.9852695,0.002255035,0.0005002525,0.01079268],"study_design_scores_gemma":[0.00001100378,0.00008389239,0.001667289,0.000003796935,0.00001624528,0.0002641215,0.00005479652,0.0006731416,0.9846272,0.0004097817,0.01218542,0.000003365374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736984,0.002979842,0.01087267,0.0009686547,0.000263892,0.00006312176,0.0008414325,0.000439993,0.009871971],"genre_scores_gemma":[0.978105,0.001388742,0.003027143,0.0002641203,0.00002927025,0.00002440128,0.0004468125,0.0000796812,0.01663482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003830261,"threshold_uncertainty_score":0.01281345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807558047042988,"score_gpt":0.2534438943592792,"score_spread":0.2353683138888493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}