{"id":"W3207342838","doi":"10.1016/j.jid.2021.08.292","title":"286 HORMAD1 Contributes to the Development of Squamous Cell Carcinomas in Melanoma Patients","year":2021,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Trametinib; Vemurafenib; HaCaT; Cancer research; Melanoma; MAPK/ERK pathway; Cell growth; Medicine; MEK inhibitor; Cell culture; Biology; Signal transduction; Cell biology; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472362,0.0002647707,0.0002297756,0.000722732,0.0003287328,0.0005767918,0.0002127968,0.0003295518,0.004248942],"category_scores_gemma":[0.0004322922,0.0002476937,0.0003256276,0.0004122391,0.0001425884,0.0001627867,0.0002311824,0.0004531049,0.0006447226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299426,"about_ca_system_score_gemma":0.0002025498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001140033,"about_ca_topic_score_gemma":0.0008336116,"domain_scores_codex":[0.9999067,0.00001660555,0.000007456197,0.00001960542,0.00002388719,0.0000257954],"domain_scores_gemma":[0.9997682,0.00003544713,0.00008954685,0.00002112805,0.00002803302,0.0000577342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004906071,0.0004094176,0.6843343,0.0002341156,0.0002000008,0.01089685,0.0002954422,0.0002704619,0.2592057,0.0008093894,0.001706061,0.03673216],"study_design_scores_gemma":[0.00005774069,0.000265553,0.9710947,0.00003237174,0.000153857,0.008874132,0.0002834988,0.0005243533,0.01384618,0.0003517287,0.004502476,0.00001350188],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957743,0.001135853,0.0002011473,0.0001423437,0.00002346933,0.00001241581,0.0005426814,0.00002632986,0.002141494],"genre_scores_gemma":[0.9968934,0.0004495242,0.000118776,0.00005289343,0.00002072641,0.000006155422,0.0003532396,0.00000776047,0.002097455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004248942,"threshold_uncertainty_score":0.01421416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307378266497812,"score_gpt":0.2243112754253823,"score_spread":0.2112374927604042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}