{"id":"W3207349528","doi":"10.7554/elife.71959.sa2","title":"Author response: Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Tuberculosis; Drug candidate; Microbiology; Drug; Medicine; Computational biology; Biology; Virology; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00152238,0.0004807897,0.0006070695,0.0003643159,0.00135144,0.001106898,0.001207281,0.003147844,0.1754411],"category_scores_gemma":[0.007936887,0.0002704232,0.0004410669,0.0003370671,0.0005394763,0.0005874081,0.000931347,0.002189505,0.04311873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002573587,"about_ca_system_score_gemma":0.003692702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01082169,"about_ca_topic_score_gemma":0.01527892,"domain_scores_codex":[0.9990048,0.0001214546,0.00003820003,0.00009338176,0.0005544521,0.0001876565],"domain_scores_gemma":[0.996394,0.0007663372,0.0001413414,0.0001649973,0.001915816,0.0006175711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005962026,0.00004211201,0.000629626,0.0003146378,0.00002372431,0.0003557327,0.00006226916,0.0003002456,0.01012515,0.0009458573,0.9767453,0.009859214],"study_design_scores_gemma":[0.0002985705,0.0003205406,0.005371767,0.0001585959,0.00003147978,0.0005720656,0.0009188624,0.001578808,0.0242379,0.001335014,0.9650719,0.0001044184],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0763335,0.00651791,0.007833204,0.4653439,0.2846642,0.001002351,0.01909501,0.003841077,0.1353689],"genre_scores_gemma":[0.1354307,0.003520396,0.004469085,0.06732601,0.007980438,0.0002280743,0.01904945,0.0009206932,0.7610752],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1754411,"threshold_uncertainty_score":0.5869088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05225142453179926,"score_gpt":0.3804132410323082,"score_spread":0.328161816500509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}