{"id":"W3207349677","doi":"10.1038/s41380-021-01327-3","title":"Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes","year":2021,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Tropomyosin receptor kinase B; Adiponectin; Endocrinology; Internal medicine; Neuroinflammation; Brain-derived neurotrophic factor; Medicine; Neurotrophic factors; Receptor; Diabetes mellitus; Inflammation; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001141205,0.0003046583,0.0003618219,0.0001831808,0.0001491759,0.00005201272,0.0004500963,0.0001695586,0.000144664],"category_scores_gemma":[0.0001620844,0.0003334373,0.0002473353,0.0007369267,0.0001958384,0.0001142689,0.0001585893,0.0003788193,0.00004288623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001562275,"about_ca_system_score_gemma":0.0001896728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001111408,"about_ca_topic_score_gemma":0.00002246577,"domain_scores_codex":[0.997511,0.0003245992,0.0004368295,0.0007976975,0.0004772441,0.0004526168],"domain_scores_gemma":[0.9987751,0.00007433979,0.0002806364,0.0006462591,0.00007566069,0.0001480065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001909848,0.0002586337,0.00260486,0.00009309454,0.00001988857,0.0003747779,0.0002454944,0.0001830284,0.9939899,0.001432609,0.0004166015,0.0003620152],"study_design_scores_gemma":[0.001106059,0.00008093027,0.004051732,0.0001216368,0.00005673736,0.0001040725,0.0003394478,0.0001026963,0.9919773,0.0008754951,0.0007848087,0.0003990794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921501,0.002266962,0.0001259305,0.001265313,0.001590507,0.0002539917,0.00002353063,0.0001618487,0.002161852],"genre_scores_gemma":[0.9964247,0.0001001412,0.0006119846,0.00248145,0.00005055705,0.00001685079,0.00001462542,0.00007989551,0.0002197359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004274696,"threshold_uncertainty_score":0.9999118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174570910597434,"score_gpt":0.2380169249417825,"score_spread":0.2262712158358081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}