{"id":"W3207398908","doi":"10.3233/jad-210700","title":"Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Internal medicine; Alzheimer's Disease Neuroimaging Initiative; Medicine; Oncology; Entorhinal cortex; Disease; Dementia; Mediation; Apolipoprotein E; Single-nucleotide polymorphism; Alzheimer's disease; Hippocampus; Biology; Genotype; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001883034,0.0005173452,0.000299885,0.0008961415,0.0003586221,0.0005997885,0.0003230294,0.0004466763,0.002005266],"category_scores_gemma":[0.005558645,0.0002071352,0.0009653166,0.0009580608,0.0003492157,0.0002506485,0.000536799,0.000755976,0.0001812196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001896049,"about_ca_system_score_gemma":0.0002857311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00496611,"about_ca_topic_score_gemma":0.004062535,"domain_scores_codex":[0.9990649,0.0004108559,0.0000860178,0.0002708704,0.00009032324,0.00007720792],"domain_scores_gemma":[0.99591,0.001676718,0.001198671,0.0005565886,0.0002866204,0.0003714044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002124575,0.00002035099,0.9966806,0.000007833974,0.0005198455,0.00006354995,0.00002751438,0.0003456837,0.0003399043,0.00005568585,0.0000827875,0.001643719],"study_design_scores_gemma":[0.000006856378,0.00006857075,0.998026,0.000002653604,0.0001111338,0.0001341685,0.00001558306,0.001392701,0.00005675619,0.000117004,0.00006445607,0.000004091257],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984622,0.0001242415,0.0006678238,0.00004415349,0.000005487725,0.000006934514,0.0004167402,0.00001717006,0.0002552715],"genre_scores_gemma":[0.9991928,0.00002429386,0.0002679737,0.000007715195,0.00000561445,0.000004882238,0.0004314641,0.000002585421,0.00006274572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00496611,"threshold_uncertainty_score":0.009958506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03098192989966978,"score_gpt":0.3421104204450376,"score_spread":0.3111284905453678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}