{"id":"W3207422538","doi":"10.3390/curroncol28050338","title":"Real World Outcomes in Patients with Advanced Melanoma Treated in Alberta, Canada: A Time-Era Based Analysis","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Cambridge Memorial Hospital; University of Calgary; Alberta Health Services","funders":"","keywords":"Medicine; Ipilimumab; Nivolumab; Melanoma; Oncology; Internal medicine; Proportional hazards model; Immunotherapy; Targeted therapy; Metastatic melanoma; Survival analysis; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006029923,0.000353301,0.0003922128,0.00120242,0.0008952347,0.0009385389,0.0007183227,0.0004204696,0.001041068],"category_scores_gemma":[0.001333375,0.0001835574,0.0004931157,0.00348147,0.000533631,0.0002991192,0.0006713869,0.0005009152,0.0001347236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0159205,"about_ca_system_score_gemma":0.009696175,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9309666,"about_ca_topic_score_gemma":0.9536379,"domain_scores_codex":[0.9993956,0.000062673,0.00004651363,0.0000820963,0.0002055629,0.0002076342],"domain_scores_gemma":[0.9984646,0.0001345925,0.0004549724,0.00007807928,0.0005135898,0.0003542376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003783549,0.00003660308,0.9951875,0.0000289106,0.0001265792,0.0001335172,0.0001231762,0.0004722559,0.0001679455,0.00007675784,0.0005415205,0.002726817],"study_design_scores_gemma":[0.00002424219,0.00007579845,0.9978896,0.00001414944,0.00006833929,0.0001107338,0.0003294463,0.0005322166,0.00006059256,0.00002902263,0.0008539488,0.00001190934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941564,0.000601414,0.0001081583,0.0001250741,0.000007547127,0.00003095367,0.003647227,0.000007458333,0.001315671],"genre_scores_gemma":[0.9958991,0.0002590818,0.0001156376,0.00008138226,0.00001078813,0.00001397714,0.003290952,0.000003547242,0.0003255163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06903344,"threshold_uncertainty_score":0.13888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200393986005751,"score_gpt":0.2725845505070179,"score_spread":0.2605806106469604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}