{"id":"W3207424466","doi":"10.1038/s41467-021-26390-w","title":"A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Canadian Institute of Mining, Metallurgy and Petroleum; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Mitacs; Genome Canada; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Burroughs Wellcome Fund","keywords":"Candida albicans; Filamentation; Corpus albicans; Biology; Microbiology; Biofilm; Lactobacillus; Context (archaeology); Yeast; Virulence; Human microbiome; Bacteria; Microbiome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035865,0.000273219,0.0002183624,0.0001526401,0.0001238769,0.0002382694,0.000166256,0.0002086578,0.0009166814],"category_scores_gemma":[0.000106462,0.0000779312,0.0001902839,0.0001098581,0.0001546903,0.0001163744,0.0001443121,0.0004349534,0.000194841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001398693,"about_ca_system_score_gemma":0.0001934847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003485853,"about_ca_topic_score_gemma":0.0005570355,"domain_scores_codex":[0.9999166,0.00001915489,0.00001050745,0.00001196231,0.00002015294,0.00002169887],"domain_scores_gemma":[0.9999402,0.00001318632,0.00001931362,0.000006182802,0.000006599534,0.00001463956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001630047,0.00003511096,0.00008320966,0.0000395656,0.000004567305,0.00003803419,0.000005573258,0.00004641396,0.9982571,0.00003643622,0.00003115432,0.001259776],"study_design_scores_gemma":[0.00002569917,0.0005815941,0.001117252,0.000005588034,0.0000096919,0.0001260585,0.00001393003,0.0001922333,0.9964928,0.0000127109,0.001418949,0.0000034839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922951,0.003800835,0.001462047,0.0002175628,0.00004575852,0.0000442303,0.0004221607,0.00005331941,0.001658869],"genre_scores_gemma":[0.9944143,0.001768364,0.002055714,0.00008240461,0.00001097526,0.0000313722,0.0004905316,0.00001129219,0.001135084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009166814,"threshold_uncertainty_score":0.003066659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02986858084619863,"score_gpt":0.2948559171046868,"score_spread":0.2649873362584882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}