{"id":"W3207451623","doi":"10.1128/jvi.01343-21","title":"Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses.","year":2022,"lang":"en","type":"article","venue":"PubMed","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Consejo Nacional de Innovación, Ciencia y Tecnología; Ministerio de Ciencia e Innovación; Ministerio de Ciencia, Innovación y Universidades","keywords":"Virology; Immunogenicity; Biology; Virus-like particle; Neutralizing antibody; Antibody; Antigen; Immune system; Virus; Trimer; Viral envelope; HIV Antigens; Immunology; Recombinant DNA; Viral disease; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008658437,0.0002997238,0.0002328744,0.000147971,0.0001555902,0.0003254361,0.0001153234,0.0003477192,0.002061408],"category_scores_gemma":[0.0005315707,0.0001097293,0.0002944256,0.00006276769,0.0002547423,0.0001723745,0.0003247877,0.0007502857,0.0004914632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001342769,"about_ca_system_score_gemma":0.0001883963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001288887,"about_ca_topic_score_gemma":0.0001785363,"domain_scores_codex":[0.9997029,0.0001094003,0.00002390858,0.00004656388,0.00004711074,0.00007009479],"domain_scores_gemma":[0.9996752,0.0001211803,0.00005030403,0.00005584778,0.00004550341,0.00005200192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000505149,0.0007048512,0.004826693,0.0001122781,0.00004113023,0.000368064,0.0001882518,0.00008863168,0.971838,0.0004628504,0.0003989906,0.02046524],"study_design_scores_gemma":[0.0004609299,0.01845859,0.07121485,0.0000688263,0.0001373478,0.008658127,0.0002185121,0.00105463,0.8793866,0.0005370731,0.01978731,0.00001725825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823232,0.001569481,0.008671853,0.0003341013,0.0001103253,0.0002345686,0.0001167588,0.0001107214,0.006529062],"genre_scores_gemma":[0.996351,0.0002697204,0.00177528,0.0001472014,0.00002793297,0.00003443234,0.0001364029,0.00000880586,0.001249259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061408,"threshold_uncertainty_score":0.006896079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091924848081222,"score_gpt":0.226487088557453,"score_spread":0.2055678400766408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}