{"id":"W3207538814","doi":"10.3390/cells10102735","title":"A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Dalhousie University; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Mitochondrial permeability transition pore; MPTP; Cell biology; Mitochondrion; Cytochrome c; Intracellular; Biology; Gene isoform; Programmed cell death; Chemistry; Molecular biology; Biochemistry; Apoptosis; Endocrinology; Dopaminergic; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255133,0.0004618871,0.0001556303,0.00007142263,0.0001391594,0.0001427711,0.0001331017,0.0001994431,0.001284314],"category_scores_gemma":[0.0001420147,0.0000816301,0.000198375,0.00004689055,0.0001442835,0.0001900163,0.000145478,0.0002933703,0.0002416262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002198108,"about_ca_system_score_gemma":0.000118567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001038201,"about_ca_topic_score_gemma":0.001109099,"domain_scores_codex":[0.99993,0.00001435318,0.000004356469,0.00001337049,0.0000150452,0.00002278001],"domain_scores_gemma":[0.9999322,0.00001253878,0.00001888569,0.000007880518,0.00001112961,0.00001752352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001046695,0.000006228445,0.00009275813,0.00002236023,0.000002178165,0.00004993852,0.00001109045,0.00001708274,0.9991942,0.00005604345,0.00001619894,0.0004272059],"study_design_scores_gemma":[0.00002738868,0.0003299331,0.01066392,0.000006021271,0.0000191654,0.0003209522,0.00003674754,0.0006870172,0.9862763,0.00006240603,0.001566259,0.000003939277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953147,0.00169301,0.001421821,0.00009285034,0.00001232401,0.0000124113,0.0001466103,0.00002976871,0.001276502],"genre_scores_gemma":[0.997043,0.0005758871,0.0007061363,0.00003074013,0.000009232466,0.00001507016,0.0001606009,0.000006344456,0.001453056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284314,"threshold_uncertainty_score":0.004296422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004901532103151343,"score_gpt":0.2340834297893709,"score_spread":0.2291818976862195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}