{"id":"W3207538814","doi":"10.3390/cells10102735","title":"A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Dalhousie University; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Mitochondrial permeability transition pore; MPTP; Cell biology; Mitochondrion; Cytochrome c; Intracellular; Biology; Gene isoform; Programmed cell death; Chemistry; Molecular biology; Biochemistry; Apoptosis; Endocrinology; Dopaminergic; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001271454,0.0001090363,0.0001524354,0.00001676742,0.00005143948,0.00001544316,0.0001374591,0.0001347176,0.00004104524],"category_scores_gemma":[0.0001967379,0.00007426168,0.000180638,0.00008627914,0.0001921744,0.000002338872,0.00006007477,0.0001364549,0.00002712138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001134623,"about_ca_system_score_gemma":0.00008828366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007631503,"about_ca_topic_score_gemma":0.000004458766,"domain_scores_codex":[0.9989371,0.0001973011,0.0001397245,0.0002764503,0.000231217,0.0002182188],"domain_scores_gemma":[0.9992758,0.0001245962,0.00002678503,0.0004104904,0.00009768472,0.00006462726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074916,0.000101217,0.0001603992,0.0001147772,0.00003671037,0.000003884471,0.0001331742,0.0000162332,0.9980273,0.00004248964,0.0008603774,0.0003959075],"study_design_scores_gemma":[0.0003498405,0.0003689295,0.003050575,0.0000236487,0.00001628948,0.000001632186,0.00004778742,0.00002349595,0.9936919,0.00007242525,0.002270072,0.00008338681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981391,0.0002640785,0.0002129768,0.0002576117,0.0004124459,0.000262031,0.00003417678,0.000005780809,0.0004117485],"genre_scores_gemma":[0.9992604,0.00009160987,0.0001000768,0.00006469832,0.0002515982,0.0000176489,0.00006290269,0.00001456594,0.0001364578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004335422,"threshold_uncertainty_score":0.3028304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004901532103151343,"score_gpt":0.2340834297893709,"score_spread":0.2291818976862195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}