{"id":"W3207551833","doi":"10.1016/j.jmoldx.2021.09.008","title":"Evaluating Targeted Next-Generation Sequencing Assays and Reference Materials for NTRK Fusion Detection","year":2021,"lang":"en","type":"article","venue":"Journal of Molecular Diagnostics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; Sunnybrook Health Science Centre; University of Toronto; Queen Elizabeth II Health Sciences Centre","funders":"Merck Sharp and Dohme; EMD Serono; Roche; Hospices Civils de Lyon; Bayer Fund; F. Hoffmann-La Roche; Merck; Boehringer Ingelheim; Amgen; Pfizer; Genentech; Bayer; AstraZeneca","keywords":"Biology; Fusion gene; Receptor tyrosine kinase; Cancer research; Kinase; Computational biology; Oncology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01866146,0.001522016,0.0009949735,0.002287493,0.0008150886,0.002243022,0.001929375,0.002884816,0.002475362],"category_scores_gemma":[0.02264657,0.0008801856,0.001182746,0.001503738,0.001252027,0.001091166,0.001207898,0.001099488,0.00215142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001626326,"about_ca_system_score_gemma":0.001584805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968352,"about_ca_topic_score_gemma":0.003756391,"domain_scores_codex":[0.9780783,0.006707165,0.001182691,0.00372761,0.009600765,0.0007034806],"domain_scores_gemma":[0.9893455,0.003260477,0.001215973,0.001177413,0.00475551,0.0002450723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001351362,0.0004256799,0.0130996,0.001191158,0.0003690453,0.0003155615,0.0004919175,0.007632425,0.9069256,0.003355912,0.002982616,0.06185929],"study_design_scores_gemma":[0.00008984555,0.001653414,0.009584746,0.0003297425,0.0003605205,0.0008732151,0.0001735214,0.02093853,0.9431301,0.001355142,0.02140502,0.0001062211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4084848,0.01508333,0.5473595,0.001203264,0.0008683607,0.00339759,0.008625481,0.004596003,0.01038161],"genre_scores_gemma":[0.4235523,0.005721997,0.5311152,0.002361142,0.000236466,0.0047584,0.02339017,0.0009977474,0.007866534],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01866146,"threshold_uncertainty_score":0.09869236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1007385083182516,"score_gpt":0.3779671981683163,"score_spread":0.2772286898500648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}