{"id":"W3207592456","doi":"10.1016/j.jtho.2021.09.008","title":"Lung Cancer Driven by BRAFG469V Mutation Is Targetable by EGFR Kinase Inhibitors","year":2021,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Compute Canada; Princess Margaret Cancer Foundation; Canadian Cancer Society; AstraZeneca","keywords":"Cancer research; Osimertinib; Gefitinib; Trametinib; Medicine; Gene knockdown; Crizotinib; Dabrafenib; Tyrosine kinase; Vemurafenib; Small interfering RNA; Kinase; Erlotinib; Lung cancer; Epidermal growth factor receptor; Mutation; Targeted therapy; Cancer; Biology; Cell culture; Oncology; MAPK/ERK pathway; Internal medicine; Gene; Melanoma; Transfection; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000712671,0.0002602634,0.0002861289,0.00008998275,0.0001849988,0.0003916337,0.0002386423,0.0002751889,0.003039532],"category_scores_gemma":[0.00007011292,0.0001290552,0.0003304185,0.0001298779,0.0001010091,0.0001444352,0.0001477518,0.0002809198,0.0006580169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004998072,"about_ca_system_score_gemma":0.0002874613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001772624,"about_ca_topic_score_gemma":0.002164946,"domain_scores_codex":[0.9999138,0.000007956295,0.000003802803,0.00001569561,0.00003695037,0.00002180918],"domain_scores_gemma":[0.9999727,0.00000428354,0.000009837433,0.000002840006,0.000004172763,0.000006088585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002919624,0.000167037,0.005171269,0.0001586004,0.00004960608,0.0006284611,0.00001654136,0.00416382,0.9750889,0.0006202739,0.0009583729,0.01268515],"study_design_scores_gemma":[0.0001844118,0.001725121,0.02454406,0.00003505364,0.0001180156,0.005822867,0.00006620622,0.02398476,0.9183062,0.0006919793,0.02449286,0.00002835505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885163,0.002612251,0.002231545,0.0001890996,0.00002880776,0.00006089932,0.0009029317,0.0002563549,0.005201817],"genre_scores_gemma":[0.9960157,0.0008883246,0.0009174107,0.00003705423,0.000005168209,0.00002078667,0.0005143445,0.000009657015,0.001591527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003039532,"threshold_uncertainty_score":0.01016825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064652298755687,"score_gpt":0.4262906330278933,"score_spread":0.4156441100403364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}