{"id":"W3207623195","doi":"10.1073/pnas.2102698118","title":"Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Bundesministerium für Bildung und Forschung; Quillen College of Medicine, East Tennessee State University; East Tennessee State University; ZonMw; Center for Sepsis Control and Care; Universitätsklinikum Jena; Deutsche Forschungsgemeinschaft; McGill University; National Health and Medical Research Council; European Commission","keywords":"Myelopoiesis; Innate immune system; Biology; Myeloid; Immunology; Haematopoiesis; Immunity; Cell biology; Population; Stem cell; Immune system; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849547,0.0002609889,0.0001464581,0.0001448261,0.000172883,0.0003330647,0.000209973,0.000231642,0.002804736],"category_scores_gemma":[0.0001191108,0.00009539908,0.000220222,0.00009457789,0.0003555688,0.0002049037,0.0003965854,0.0005016477,0.000316855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001939652,"about_ca_system_score_gemma":0.0001715979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001828254,"about_ca_topic_score_gemma":0.0003738705,"domain_scores_codex":[0.9998895,0.00001834428,0.000007198852,0.0000363932,0.00002359083,0.00002502232],"domain_scores_gemma":[0.9999199,0.000007168981,0.00002845602,0.00001597833,0.000008725168,0.00001972633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002795153,0.0000731687,0.001790404,0.0001427417,0.00002411127,0.0002974678,0.0000453726,0.00006391938,0.9841478,0.001076728,0.0003460741,0.01171267],"study_design_scores_gemma":[0.00007029632,0.001389306,0.1083694,0.00008470286,0.00008163269,0.002826805,0.0001958188,0.001435867,0.8629676,0.001672115,0.02087574,0.00003070775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704602,0.01134258,0.009946399,0.000604026,0.0003191157,0.00007043629,0.0004196593,0.0002187303,0.006618881],"genre_scores_gemma":[0.9888434,0.002636772,0.00168754,0.0001942579,0.00006249977,0.0000468769,0.0003309799,0.00001936476,0.006178329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002804736,"threshold_uncertainty_score":0.009382725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02911117667702057,"score_gpt":0.2868406970593991,"score_spread":0.2577295203823785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}