{"id":"W3207634490","doi":"10.1139/cjm-2021-0053","title":"Deletion of the type IV secretion system promoter <i>VirB</i> in <i>Brucella abortus</i> A19 strain attenuated the virulence of the bacteria and promotes autophagy","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Brucella: diagnosis, epidemiology, treatment","field":"Veterinary","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Virulence; Microbiology; Secretion; Mutant; Brucellaceae; Brucella; Biology; Strain (injury); Downregulation and upregulation; Brucella melitensis; Virology; Gene; Genetics; Brucellosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00101966,0.0001883225,0.0004686615,0.00008487525,0.0001082148,0.0000131135,0.0004166763,0.0002475597,0.00007933335],"category_scores_gemma":[0.0003145072,0.0001047857,0.0001385515,0.0002689835,0.0004763634,0.00004474868,0.00006822582,0.0003783186,0.000003806377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392862,"about_ca_system_score_gemma":0.0009331332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002466952,"about_ca_topic_score_gemma":0.01459459,"domain_scores_codex":[0.9969358,0.001647007,0.0008070532,0.000226526,0.00005513819,0.0003285109],"domain_scores_gemma":[0.9981464,0.0002874138,0.0007654112,0.0004054996,0.0002920205,0.0001033135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000734495,0.00004022323,0.03304651,0.0001023342,0.0001127609,0.0001126502,0.0006985688,0.00002395592,0.9642926,0.0002353239,0.0007816875,0.0004799574],"study_design_scores_gemma":[0.002764206,0.001925816,0.7918195,0.002494173,0.0003946232,0.01732801,0.001465467,0.0002353686,0.1687235,0.0005474327,0.01179326,0.0005086463],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929433,0.002029737,0.000004727253,0.003548182,0.0007869349,0.0003705374,0.0002474215,0.000003525931,0.00006556419],"genre_scores_gemma":[0.9992365,0.00009427319,0.0001180542,0.0004159009,0.00005800178,0.00000628272,0.00001738425,0.00001742945,0.00003613046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7955691,"threshold_uncertainty_score":0.8144126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02584083466483177,"score_gpt":0.2532669454818154,"score_spread":0.2274261108169837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}