{"id":"W3207634490","doi":"10.1139/cjm-2021-0053","title":"Deletion of the type IV secretion system promoter <i>VirB</i> in <i>Brucella abortus</i> A19 strain attenuated the virulence of the bacteria and promotes autophagy","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Brucella: diagnosis, epidemiology, treatment","field":"Veterinary","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Virulence; Microbiology; Secretion; Mutant; Brucellaceae; Brucella; Biology; Strain (injury); Downregulation and upregulation; Brucella melitensis; Virology; Gene; Genetics; Brucellosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527443,0.0004930231,0.0002906698,0.0002489105,0.0001495874,0.0002870661,0.0003279874,0.0003159317,0.001287803],"category_scores_gemma":[0.0001473628,0.0001751891,0.0005331521,0.000203498,0.0002661179,0.0001738432,0.0002514178,0.0006778122,0.0005019935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003531907,"about_ca_system_score_gemma":0.0002976666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002298368,"about_ca_topic_score_gemma":0.001717152,"domain_scores_codex":[0.9997719,0.0000325332,0.00004247899,0.00003717031,0.00006479867,0.00005109822],"domain_scores_gemma":[0.9998114,0.00002713341,0.00007320147,0.00002794737,0.00002088553,0.00003951327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005994581,0.00003347505,0.000132837,0.00001559656,0.000004092639,0.00002769283,0.000007630113,0.00002463827,0.9993196,0.00004383935,0.0000242531,0.0003065374],"study_design_scores_gemma":[0.00002679052,0.0004054585,0.005733556,0.00001231623,0.00002185153,0.0002579656,0.00004914081,0.00109837,0.9895716,0.000031432,0.002781311,0.00001031904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946378,0.0003334977,0.00288072,0.0001057712,0.00006055527,0.00004457136,0.0008818495,0.0000988016,0.0009564278],"genre_scores_gemma":[0.9887586,0.0003391389,0.004848226,0.0001071622,0.00001862658,0.0000580831,0.003100201,0.0001122553,0.002657683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002298368,"threshold_uncertainty_score":0.004569948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02584083466483177,"score_gpt":0.2532669454818154,"score_spread":0.2274261108169837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}