{"id":"W3207672631","doi":"10.1093/nar/gkab957","title":"webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":366,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Alberta Children's Hospital; University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Genome-wide association study; Biology; Software; Computational biology; Genetic association; Computer science; Data science; Gene; Genetics; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002405211,0.002169531,0.00285644,0.008332996,0.0009060303,0.002828986,0.003855096,0.001415436,0.1146421],"category_scores_gemma":[0.00854286,0.001501539,0.002686547,0.009232916,0.0004269707,0.001995455,0.003848756,0.002047796,0.05544905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006017476,"about_ca_system_score_gemma":0.002480038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002987717,"about_ca_topic_score_gemma":0.005668881,"domain_scores_codex":[0.9984854,0.0003136582,0.0002959726,0.0003845874,0.0003631984,0.0001571762],"domain_scores_gemma":[0.9936863,0.003213609,0.0009816893,0.0008792944,0.0005541992,0.0006850496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001624113,0.0001584108,0.01123406,0.007397569,0.0009601871,0.001493234,0.0003372906,0.002067237,0.01715179,0.005506827,0.8718728,0.08019646],"study_design_scores_gemma":[0.001653898,0.0002136933,0.03692325,0.001147453,0.0008767518,0.002765395,0.0002398905,0.00901098,0.01456728,0.02789291,0.9042928,0.0004157047],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"software","genre_scores_codex":[0.004532683,0.001729496,0.04848851,0.0004476263,0.0002625427,0.0002614852,0.8713394,0.06757177,0.005366425],"genre_scores_gemma":[0.01429982,0.001676462,0.08667874,0.0007322327,0.000220861,0.001149649,0.8727136,0.01858996,0.003938633],"genre_candidate":"software","genre_consensus":null,"teacher_disagreement_score":0.1146421,"threshold_uncertainty_score":0.3835159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03305318693027964,"score_gpt":0.3478255143038149,"score_spread":0.3147723273735352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}