{"id":"W3207702167","doi":"10.1016/j.jneuroim.2021.577745","title":"Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3","year":2021,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Purinergic receptor; Signal transduction; Knockout mouse; Neuroscience; Cell biology; TLR4; Secretion; Purinergic signalling; Neuroinflammation; Immune system; Biology; Immunology; Inflammation; Receptor; Endocrinology; Extracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686401,0.000329379,0.0001835842,0.0002833598,0.000288915,0.0005425321,0.000232281,0.0002914576,0.001727598],"category_scores_gemma":[0.00021934,0.0001645927,0.0004057109,0.0001323065,0.0003073379,0.0004058941,0.000486379,0.0008082396,0.0002982958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003501307,"about_ca_system_score_gemma":0.0002752148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007187226,"about_ca_topic_score_gemma":0.00155643,"domain_scores_codex":[0.9997868,0.00002265692,0.00002056332,0.00003518153,0.00006759129,0.00006715464],"domain_scores_gemma":[0.9998554,0.00001806703,0.00004244601,0.00001475961,0.00002129651,0.0000480031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000379905,0.00001970241,0.002082793,0.00002893325,0.000009083107,0.0003551642,0.00005471914,0.0001051286,0.9949607,0.0005046544,0.00008716029,0.001412064],"study_design_scores_gemma":[0.0000846454,0.0003517181,0.07036795,0.00003019662,0.00005065453,0.001250588,0.0005815788,0.002651675,0.9218163,0.001113744,0.00168289,0.00001805718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947413,0.0006516176,0.002231564,0.0002664214,0.0000438947,0.0000116477,0.0004220842,0.00005823805,0.001573268],"genre_scores_gemma":[0.9967173,0.0002861887,0.001076635,0.00007819846,0.00001214604,0.00002143208,0.0002025117,0.00001336163,0.001592207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727598,"threshold_uncertainty_score":0.005779445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006525020170880871,"score_gpt":0.2044400452622029,"score_spread":0.1979150250913221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}