{"id":"W3207736600","doi":"10.1016/j.jtho.2021.08.708","title":"P69.03 Chemotherapy Upregulates PD-L1 Expression and Activates cGAS-STING Pathway in Non-Small Cell Lung Cancer Models","year":2021,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Chemotherapy; Cancer research; Lung cancer; Cisplatin; Sting; Immunotherapy; Pembrolizumab; Cell; Cell culture; Cancer; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458802,0.0004651208,0.0004152224,0.0004267954,0.0003455743,0.0004319449,0.0002800176,0.000437294,0.003989014],"category_scores_gemma":[0.0001096344,0.0001479767,0.0004914096,0.000358906,0.0003010081,0.0002864245,0.0001694755,0.00166159,0.0007606634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941534,"about_ca_system_score_gemma":0.0007199267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001376322,"about_ca_topic_score_gemma":0.002963421,"domain_scores_codex":[0.9997303,0.00003182611,0.00001590637,0.00003223433,0.00006914343,0.0001206427],"domain_scores_gemma":[0.9999187,0.000008762174,0.00002062864,0.000009799983,0.000008856096,0.00003325145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007282929,0.004887432,0.001834898,0.000340799,0.00007738138,0.0006323546,0.00009939908,0.001276734,0.9513155,0.001033397,0.006075962,0.02514323],"study_design_scores_gemma":[0.001036173,0.01979199,0.01374073,0.00004194634,0.0001795235,0.0009086357,0.0002137353,0.007013004,0.9417089,0.0005387088,0.01478933,0.00003735064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879381,0.001512542,0.001727584,0.000515455,0.000349356,0.0001736861,0.001704415,0.0003436607,0.005735209],"genre_scores_gemma":[0.9929962,0.0007793665,0.0007482183,0.0001437911,0.00003544261,0.000168384,0.001162722,0.00001952016,0.003946463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003989014,"threshold_uncertainty_score":0.01334459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657342501882777,"score_gpt":0.3344446957343933,"score_spread":0.3178712707155655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}