{"id":"W3207758744","doi":"10.1093/brain/awab404","title":"Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Association for Frontotemporal Degeneration; National Institutes of Health; Parkinson Canada; Little Family Foundation; Motor Neurone Disease Association; Cytokinetics; Brain Research UK; Biogen; University of Miami; Prothena; Alexion Pharmaceuticals; Tau Consortium; National Institute on Aging; National Institute for Health and Care Research; Medical Research Council; Teva Pharmaceutical Industries; Acorda Therapeutics; Mitsubishi Tanabe Pharma Corporation; ALS Association; Genentech; Muscular Dystrophy Association; AveXis; Alzheimer's Association","keywords":"Amyotrophic lateral sclerosis; Frontotemporal dementia; Disease; Medicine; Neuroscience; Progressive muscular atrophy; Atrophy; C9orf72; Dementia; Pathology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002041031,0.0009435056,0.001203687,0.00111508,0.0005119689,0.001672764,0.001025628,0.001552553,0.002589472],"category_scores_gemma":[0.003121292,0.0002383146,0.0006926919,0.0005146617,0.001466863,0.002748249,0.001609738,0.004244696,0.001063718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00146077,"about_ca_system_score_gemma":0.002628549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001945006,"about_ca_topic_score_gemma":0.004062292,"domain_scores_codex":[0.9995031,0.000143698,0.00005630226,0.00008812124,0.0001395267,0.00006913648],"domain_scores_gemma":[0.998247,0.0006970963,0.0001735135,0.00008587668,0.0004921478,0.0003042973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007460144,0.0007298775,0.005334627,0.008082268,0.0002809477,0.0009740162,0.00105502,0.0008080225,0.008923129,0.04152391,0.04594649,0.8855957],"study_design_scores_gemma":[0.000452379,0.002969844,0.02459087,0.01688456,0.0007884189,0.004176908,0.002180723,0.001867004,0.006342076,0.1486268,0.7909359,0.0001844902],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007988768,0.949355,0.003487407,0.03136048,0.001214904,0.00003717305,0.0001685853,0.0001079585,0.006279794],"genre_scores_gemma":[0.07102484,0.9062216,0.007290943,0.00984214,0.002646618,0.000117257,0.0002287877,0.00003691457,0.002591004],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002589472,"threshold_uncertainty_score":0.0107941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02811961247760569,"score_gpt":0.2802196708056781,"score_spread":0.2521000583280724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}