{"id":"W3207758744","doi":"10.1093/brain/awab404","title":"Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Association for Frontotemporal Degeneration; National Institutes of Health; Parkinson Canada; Little Family Foundation; Motor Neurone Disease Association; Cytokinetics; Brain Research UK; Biogen; University of Miami; Prothena; Alexion Pharmaceuticals; Tau Consortium; National Institute on Aging; National Institute for Health and Care Research; Medical Research Council; Teva Pharmaceutical Industries; Acorda Therapeutics; Mitsubishi Tanabe Pharma Corporation; ALS Association; Genentech; Muscular Dystrophy Association; AveXis; Alzheimer's Association","keywords":"Amyotrophic lateral sclerosis; Frontotemporal dementia; Disease; Medicine; Neuroscience; Progressive muscular atrophy; Atrophy; C9orf72; Dementia; Pathology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007402807,0.0002712123,0.0004736115,0.00009797607,0.0001746697,0.0001391786,0.0001817069,0.0001180182,0.0008441189],"category_scores_gemma":[0.0006041238,0.0002244872,0.0002052168,0.0004289163,0.0001110959,0.0002416794,0.0002497687,0.0003391366,0.0001751155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011686,"about_ca_system_score_gemma":0.0002590704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001111696,"about_ca_topic_score_gemma":0.0000384107,"domain_scores_codex":[0.9973278,0.0004342386,0.0004366114,0.0006619767,0.0006583331,0.0004810641],"domain_scores_gemma":[0.9984725,0.0002402896,0.00009933622,0.0006165657,0.0001870125,0.0003842555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003049464,0.0008406242,0.0430607,0.0002320547,0.0004524869,0.0008328852,0.00262294,0.0001235717,0.9363594,0.0003519999,0.006401949,0.00841646],"study_design_scores_gemma":[0.001960979,0.0001736022,0.9781349,0.0006917219,0.0001125369,0.00002179295,0.00006006504,0.00339919,0.01347073,0.001169791,0.0005409469,0.0002637334],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910086,0.001556754,0.0001189156,0.006162319,0.000179511,0.0004683248,0.00004957348,0.000170448,0.0002856022],"genre_scores_gemma":[0.9925738,0.00009690363,0.001218926,0.002118204,0.0005768252,0.00009582474,0.000250423,0.0000620492,0.003007028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9350742,"threshold_uncertainty_score":0.924251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02811961247760569,"score_gpt":0.2802196708056781,"score_spread":0.2521000583280724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}