{"id":"W3207788598","doi":"10.1016/j.chom.2021.09.010","title":"Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection","year":2021,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital","funders":"National Institute of Allergy and Infectious Diseases; Pew Charitable Trusts; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Kenneth Rainin Foundation; Burroughs Wellcome Fund","keywords":"Biology; Retinoic acid; Segmented filamentous bacteria; Citrobacter rodentium; Bacteria; Microbiology; Host (biology); Gut flora; Pathogen; Histone; Immunology; Cell biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002101857,0.000322589,0.0003028677,0.000253739,0.0001995692,0.0004714536,0.0001597649,0.0004224853,0.002187037],"category_scores_gemma":[0.000329467,0.0001471875,0.0002345036,0.0001072,0.0003577496,0.0002596727,0.0003075401,0.0008037791,0.0004098069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000367094,"about_ca_system_score_gemma":0.0003566065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003078059,"about_ca_topic_score_gemma":0.0007843744,"domain_scores_codex":[0.9997309,0.00008202584,0.00001089821,0.00003723542,0.00003700355,0.000102015],"domain_scores_gemma":[0.9997253,0.00005425954,0.00005195545,0.00003692287,0.00002412749,0.000107493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001682646,0.00004291557,0.0003806252,0.00002943488,0.000003677716,0.00007349859,0.0000273468,0.00007030347,0.9955064,0.0001593631,0.00006052556,0.001963185],"study_design_scores_gemma":[0.0001434487,0.002389443,0.02317788,0.00003704641,0.00003523799,0.0003454231,0.0005426758,0.001323656,0.9684994,0.0004710332,0.003021395,0.00001350135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946943,0.001845699,0.0008782377,0.0002109804,0.00007748363,0.00001467193,0.0001392168,0.00005996642,0.002079514],"genre_scores_gemma":[0.9969987,0.0005039146,0.000602544,0.00005545196,0.00002726266,0.00001208581,0.0000849327,0.00001196916,0.001703256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002187037,"threshold_uncertainty_score":0.007316411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010985042619131,"score_gpt":0.2261717408437546,"score_spread":0.2160618904175633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}