{"id":"W3207788598","doi":"10.1016/j.chom.2021.09.010","title":"Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection","year":2021,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital","funders":"National Institute of Allergy and Infectious Diseases; Pew Charitable Trusts; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Kenneth Rainin Foundation; Burroughs Wellcome Fund","keywords":"Biology; Retinoic acid; Segmented filamentous bacteria; Citrobacter rodentium; Bacteria; Microbiology; Host (biology); Gut flora; Pathogen; Histone; Immunology; Cell biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000165799,0.0003501004,0.0003575939,0.000170664,0.0003436094,0.00009329135,0.0001535844,0.0002702266,0.008116751],"category_scores_gemma":[0.0001383226,0.0003701494,0.0001792344,0.0002426966,0.00009990888,0.0001592723,0.0002514201,0.0005276849,0.005950085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105699,"about_ca_system_score_gemma":0.0001127046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000135205,"about_ca_topic_score_gemma":0.00003567959,"domain_scores_codex":[0.9980342,0.000348065,0.0004859147,0.0005583778,0.00004581944,0.0005276641],"domain_scores_gemma":[0.9988665,0.00009095306,0.000200254,0.0004649909,0.0003129512,0.00006435055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003794107,0.0003562034,0.0009765635,0.00003280872,0.00008459505,0.00001992165,0.000568073,0.000001413905,0.9192746,0.000008791127,0.07793676,0.0003608769],"study_design_scores_gemma":[0.001042061,0.0003164936,0.007127313,0.00007644311,0.00005341274,0.0003311933,0.0002360931,0.000001376155,0.7141383,0.000001648631,0.2764021,0.0002735646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840985,0.001072197,0.001259851,0.0005283318,0.007250882,0.0003808996,0.0000203193,0.0002463327,0.005142685],"genre_scores_gemma":[0.9572941,0.0001546662,0.0006059998,0.002415974,0.0000929751,0.00003882886,0.00105147,0.00005501668,0.03829095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2051362,"threshold_uncertainty_score":0.9998751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010985042619131,"score_gpt":0.2261717408437546,"score_spread":0.2160618904175633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}