{"id":"W3207812142","doi":"10.1101/2021.10.08.463692","title":"NOD1 is super-activated through spatially-selective ubiquitination by the <i>Salmonella</i> effector SspH2","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Alberta; Government of Alberta","keywords":"Effector; Ubiquitin; Salmonella; Chemistry; Biology; Cell biology; Genetics; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101702,0.0002955809,0.0001372818,0.0001409629,0.0001469519,0.0002100176,0.0001152377,0.0001384311,0.001945167],"category_scores_gemma":[0.00005456628,0.0001061422,0.0001869873,0.00008130598,0.0001393942,0.000108497,0.0001836886,0.0002779143,0.0005905395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003217419,"about_ca_system_score_gemma":0.0001139701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002805981,"about_ca_topic_score_gemma":0.0004609406,"domain_scores_codex":[0.9999137,0.00001368639,0.000008966445,0.00001732519,0.00002849851,0.00001788704],"domain_scores_gemma":[0.9999554,0.000005141272,0.00001167355,0.000005938485,0.000005779412,0.00001609881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000114008,0.000008782413,0.0002969079,0.00002132707,0.000002770256,0.00005212429,0.000002665468,0.00003414927,0.9989705,0.00005204754,0.00006355494,0.0003813267],"study_design_scores_gemma":[0.0000196818,0.0002014993,0.007760197,0.000004729071,0.000008345194,0.0006291292,0.00002227474,0.001050452,0.9864683,0.00004788096,0.003783312,0.000004129504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914228,0.000930315,0.003551855,0.0001260814,0.00004344526,0.00002635485,0.0006707876,0.0001627147,0.003065533],"genre_scores_gemma":[0.9911056,0.0004051113,0.00262918,0.00007034963,0.00001281636,0.00001656338,0.001139155,0.00003012082,0.004591143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001945167,"threshold_uncertainty_score":0.006507218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054321505699284,"score_gpt":0.2453152518883923,"score_spread":0.2347720368313995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}