{"id":"W3207828649","doi":"10.1021/acschembio.1c00501","title":"Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia; University of Alberta","funders":"Canada Excellence Research Chairs, Government of Canada; Alberta Innovates; Canada Research Chairs; Arthritis Society; Natural Sciences and Engineering Research Council of Canada; Government of Alberta","keywords":"SIGLEC; Sulfation; Glycan; Chemistry; Biochemistry; Sialic acid; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690098,0.0003380573,0.0001726298,0.0001279303,0.000103934,0.0003830986,0.0002069094,0.0002085201,0.000485179],"category_scores_gemma":[0.0001083634,0.0001328753,0.0002145027,0.0000961289,0.0002399551,0.0002351901,0.0002468631,0.0004707932,0.0001968843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000226476,"about_ca_system_score_gemma":0.0001326341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002948441,"about_ca_topic_score_gemma":0.0004397872,"domain_scores_codex":[0.9998671,0.00002130706,0.000008767262,0.00002281717,0.0000436005,0.00003629749],"domain_scores_gemma":[0.999916,0.00001344009,0.00002370175,0.00001701791,0.00001314094,0.00001674511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001779428,0.000003765143,0.0001544854,0.000007646418,0.000001490614,0.00001111239,0.000004802236,0.00004028309,0.9992017,0.00007474059,0.000008159901,0.0004739554],"study_design_scores_gemma":[0.000004220443,0.00008662113,0.002037756,0.000001736555,0.000006560732,0.00007544551,0.0000157894,0.0007636415,0.9957936,0.00005645899,0.001155443,0.000002720187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929791,0.0007277995,0.005069829,0.00009127141,0.00001976888,0.00001732383,0.00007447098,0.00007685846,0.0009435584],"genre_scores_gemma":[0.9955181,0.0005106425,0.002899479,0.00006198655,0.000009349765,0.00001327505,0.00008484887,0.00001388634,0.0008884598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000485179,"threshold_uncertainty_score":0.00164324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01644698490205676,"score_gpt":0.2956447163092666,"score_spread":0.2791977314072099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}