{"id":"W3207855541","doi":"10.1186/s12885-021-08808-2","title":"Rationale and design of the Diet Restriction and Exercise-induced Adaptations in Metastatic breast cancer (DREAM) study: a 2-arm, parallel-group, phase II, randomized control trial of a short-term, calorie-restricted, and ketogenic diet plus exercise during intravenous chemotherapy versus usual care","year":2021,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Diet and metabolism studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Medicine; Breast cancer; Calorie restriction; Chemotherapy; Internal medicine; Aerobic exercise; Surgical oncology; Cancer; Randomized controlled trial; Calorie; Sports medicine; Oncology; Metastatic breast cancer; Endurance training; Physical therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01958611,0.004694799,0.006149071,0.001371768,0.002141729,0.00195348,0.003458723,0.00492606,0.01405148],"category_scores_gemma":[0.01125783,0.002533406,0.002355747,0.001138696,0.004082715,0.001641885,0.001472509,0.006460774,0.003911592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001455145,"about_ca_system_score_gemma":0.008340864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009001413,"about_ca_topic_score_gemma":0.001776669,"domain_scores_codex":[0.9855396,0.009757552,0.0007177114,0.001308536,0.001561061,0.001115674],"domain_scores_gemma":[0.9954803,0.001032107,0.000807261,0.0004385615,0.0005881441,0.001653548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9285228,0.03090499,0.002273391,0.003571033,0.0008773365,0.000167879,0.0002298716,0.001230203,0.004657854,0.002130212,0.003909075,0.02152547],"study_design_scores_gemma":[0.8926539,0.0900948,0.003232993,0.0003863663,0.0006540508,0.00006643623,0.00006157927,0.001053131,0.0007771506,0.001154031,0.009788011,0.00007757071],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.06526509,0.002704303,0.005485817,0.002062842,0.002000942,0.9160565,0.002508582,0.000245932,0.00367001],"genre_scores_gemma":[0.04995672,0.0009321562,0.0100495,0.002036947,0.0004371294,0.9341401,0.0005971136,0.00001542705,0.001834959],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01958611,"threshold_uncertainty_score":0.1035825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.046537178688737,"score_gpt":0.3222471839097432,"score_spread":0.2757100052210062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}