{"id":"W3207857357","doi":"10.1101/2021.10.20.465143","title":"The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Sorbonne Université; Agence Nationale de la Recherche; Canadian Institutes of Health Research; Université de Recherche Paris Sciences et Lettres; National Cancer Institute; Institut National Du Cancer; University of Ottawa","keywords":"Biology; Cell biology; Cell cycle; Cell cycle checkpoint; Telomere; DNA damage; Adaptation (eye); G2-M DNA damage checkpoint; Genetics; Cell; DNA; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009842651,0.0003060108,0.0001574738,0.0002672233,0.0001771575,0.0003988949,0.0001312181,0.0002263683,0.0008835719],"category_scores_gemma":[0.00009669486,0.0001235295,0.0001604197,0.0001780494,0.0002121773,0.000172573,0.000225059,0.0003440656,0.0002902533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003473827,"about_ca_system_score_gemma":0.0001455582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007966051,"about_ca_topic_score_gemma":0.0007859647,"domain_scores_codex":[0.9999286,0.000007470325,0.00000538307,0.00002108484,0.00001808703,0.00001934243],"domain_scores_gemma":[0.9999435,0.000006018995,0.00001629625,0.000006937481,0.000007536664,0.00001975232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001300699,0.00000811018,0.0005975144,0.00001992449,0.000002870315,0.00006796305,0.000009249812,0.00005560472,0.9981599,0.0001247029,0.00003352599,0.0007905727],"study_design_scores_gemma":[0.00001036047,0.00005083023,0.03324223,0.000007892719,0.00001232385,0.0002254345,0.00003628418,0.001057203,0.9637004,0.0001612634,0.001491414,0.000004408383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929558,0.002767722,0.002015792,0.0001258533,0.00003064023,0.00001069908,0.0004381888,0.00007028189,0.001585009],"genre_scores_gemma":[0.9963368,0.0004687516,0.0005362987,0.00002508173,0.000005215727,0.000008046691,0.0004201576,0.00001257077,0.002187081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008835719,"threshold_uncertainty_score":0.002955854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660286556995067,"score_gpt":0.2249508122340482,"score_spread":0.2083479466640976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}