{"id":"W3208018381","doi":"10.1007/s11064-021-03471-2","title":"Resiniferatoxin Hampers the Nocifensive Response of Caenorhabditis elegans to Noxious Heat, and Pathway Analysis Revealed that the Wnt Signaling Pathway is Involved","year":2021,"lang":"en","type":"article","venue":"Neurochemical Research","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Quebec Network for Research on Aging; Cegep de Saint Hyacinthe; Université de Montréal","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Resiniferatoxin; Caenorhabditis elegans; TRPV1; TRPV; Transient receptor potential channel; Noxious stimulus; Cell biology; Chemistry; Receptor; Signal transduction; Pharmacology; Capsaicin; Nociception; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009308777,0.000503522,0.000202036,0.0002785308,0.0001584048,0.000163155,0.0001700001,0.000238234,0.001437848],"category_scores_gemma":[0.00009943062,0.0001692436,0.0002049666,0.00006259775,0.0002117814,0.0001600402,0.0001628657,0.0005078043,0.0002128955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003912406,"about_ca_system_score_gemma":0.0002326618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001917054,"about_ca_topic_score_gemma":0.007339901,"domain_scores_codex":[0.9999199,0.000004671382,0.000006930942,0.00002251346,0.00002074785,0.00002524569],"domain_scores_gemma":[0.9998524,0.00001324852,0.00004822269,0.00001663235,0.00001580138,0.00005358631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008068811,0.00001180918,0.00008275951,0.00001275325,0.000002621935,0.00002447006,0.000003375832,0.00002898181,0.999343,0.00001744746,0.00001831365,0.0003737731],"study_design_scores_gemma":[0.00002824001,0.0003519454,0.01408079,0.00001044204,0.00001871995,0.0001218205,0.00002553957,0.000740067,0.9834873,0.00004213627,0.001084463,0.000008442948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978479,0.0003809485,0.0005888209,0.000067444,0.00003039105,0.000009122193,0.0002747408,0.00008568931,0.0007148703],"genre_scores_gemma":[0.9932663,0.0005880828,0.001296576,0.00008652505,0.000008408314,0.00002205689,0.0003596114,0.00003159465,0.004340957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917054,"threshold_uncertainty_score":0.004810035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04311978432042311,"score_gpt":0.3082080100030812,"score_spread":0.2650882256826581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}