{"id":"W3208018381","doi":"10.1007/s11064-021-03471-2","title":"Resiniferatoxin Hampers the Nocifensive Response of Caenorhabditis elegans to Noxious Heat, and Pathway Analysis Revealed that the Wnt Signaling Pathway is Involved","year":2021,"lang":"en","type":"article","venue":"Neurochemical Research","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Quebec Network for Research on Aging; Cegep de Saint Hyacinthe; Université de Montréal","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Resiniferatoxin; Caenorhabditis elegans; TRPV1; TRPV; Transient receptor potential channel; Noxious stimulus; Cell biology; Chemistry; Receptor; Signal transduction; Pharmacology; Capsaicin; Nociception; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001666559,0.0002320607,0.0003378235,0.0001234574,0.0003629014,0.0001094602,0.0005674446,0.0002153323,0.00003937706],"category_scores_gemma":[0.002430521,0.0001660334,0.0002169657,0.00085395,0.0004919081,0.000004845943,0.0006282791,0.0005639496,0.000006367673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000319544,"about_ca_system_score_gemma":0.0004088298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001257078,"about_ca_topic_score_gemma":0.0002290304,"domain_scores_codex":[0.9962296,0.001235026,0.0003508514,0.0007824409,0.0008079305,0.0005940871],"domain_scores_gemma":[0.9970722,0.0007379046,0.00006076921,0.001045625,0.0008235343,0.0002599534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004369862,0.00005653314,0.00249187,0.00002338937,0.0001704356,0.00004431202,0.002005319,0.000070461,0.9929759,0.00002059561,0.001591346,0.0001128809],"study_design_scores_gemma":[0.000313129,0.0002815477,0.003797742,0.00001869813,0.0000632476,0.00001971455,0.001352408,0.00008784096,0.9901474,0.0001177815,0.003622049,0.0001784782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916893,0.001406986,0.0003474549,0.006005959,0.00005023338,0.0003415828,0.00008202556,0.000008987686,0.00006745323],"genre_scores_gemma":[0.9960063,0.0003308847,0.0002344011,0.002568927,0.0001385439,0.00003639785,0.00004541382,0.00003854986,0.0006005859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004316979,"threshold_uncertainty_score":0.6770644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04311978432042311,"score_gpt":0.3082080100030812,"score_spread":0.2650882256826581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}