{"id":"W3208034322","doi":"10.1016/j.ijrobp.2021.07.1306","title":"The First-in-Class UBA1 Inhibitor, TAK-243, in Combination With Radiotherapy for YAP1 and BEND3 Biomarker-Defined Small Cell Lung Cancer","year":2021,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Sinai Health System; Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Medicine; In vivo; Biomarker; Cancer research; Cancer; Ex vivo; Lung cancer; Oncology; Proteasome inhibitor; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003427132,0.000478559,0.0008509877,0.0003323272,0.0003131127,0.0005325482,0.0004591923,0.0003399294,0.002592281],"category_scores_gemma":[0.0001947977,0.0001949408,0.000703503,0.0002594569,0.0002210049,0.0003714849,0.0002973109,0.001319375,0.000417388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004271269,"about_ca_system_score_gemma":0.0005253642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004650958,"about_ca_topic_score_gemma":0.002405946,"domain_scores_codex":[0.9998707,0.00001984262,0.000009947435,0.00002381299,0.00002833558,0.00004738434],"domain_scores_gemma":[0.9999334,0.00001039502,0.00001381568,0.000007751547,0.000006328921,0.00002830535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04827057,0.004536938,0.004611759,0.001187824,0.0008811026,0.0007408559,0.0001705304,0.0031665,0.685423,0.0009277043,0.006551803,0.2435315],"study_design_scores_gemma":[0.009322749,0.06837498,0.02489903,0.0001291355,0.001748561,0.004205109,0.0002800273,0.01030902,0.8452704,0.0007488597,0.03457507,0.0001370559],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728627,0.0184708,0.002345189,0.0006608235,0.0003370876,0.0002167743,0.0006581409,0.0003610007,0.004087405],"genre_scores_gemma":[0.9926217,0.003608643,0.001316175,0.0001424068,0.00004150441,0.000103271,0.0005687176,0.00002794104,0.001569697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002592281,"threshold_uncertainty_score":0.008672118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158151854191995,"score_gpt":0.3117956922076235,"score_spread":0.295980506788424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}