{"id":"W3208099852","doi":"10.14309/01.ajg.0000777120.59385.ef","title":"S897 Impact of Mirikizumab Therapy on Histologic Measures of Intestinal Inflammation in a Phase 2 Study of Patients With Moderately- to Severely-Active Crohn’s Disease","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Medicine; Gastroenterology; Ileitis; Internal medicine; Ascending colon; Crohn's disease; Clinical endpoint; Ileum; Rectum; Randomized controlled trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00230826,0.00106347,0.002037991,0.000293379,0.0003203142,0.0008127879,0.0004577832,0.0008952739,0.003496336],"category_scores_gemma":[0.0009354174,0.0005475858,0.001525204,0.0003042873,0.0005572984,0.0006812614,0.0003210228,0.001870735,0.0007289588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004223718,"about_ca_system_score_gemma":0.0009364384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003438052,"about_ca_topic_score_gemma":0.0009568174,"domain_scores_codex":[0.9993673,0.0003873378,0.0000432897,0.00007085856,0.00005531554,0.00007603901],"domain_scores_gemma":[0.9993213,0.0001378725,0.0001568213,0.00005586082,0.00006155899,0.0002666254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8785222,0.03517801,0.006671221,0.0006202909,0.001088712,0.0001324932,0.0001169039,0.0004540113,0.03262528,0.00006879165,0.001173231,0.04334888],"study_design_scores_gemma":[0.3847698,0.5850222,0.0243406,0.00003429525,0.0006761883,0.0001420432,0.00004377444,0.0005218757,0.002850419,0.0000638078,0.001511715,0.0000233653],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953348,0.001725077,0.0002201306,0.0002333047,0.0000973119,0.00103029,0.0004817061,0.00002783349,0.0008495717],"genre_scores_gemma":[0.9932076,0.001239382,0.0009236556,0.0004750775,0.0001984587,0.00129137,0.001206129,0.00001505015,0.001443278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003496336,"threshold_uncertainty_score":0.01220739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426369538250425,"score_gpt":0.2781461532521367,"score_spread":0.2638824578696324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}