{"id":"W3208152686","doi":"10.12688/wellcomeopenres.15846.1","title":"Variants associated with HHIP expression have sex-differential effects on lung function","year":2020,"lang":"en","type":"preprint","venue":"Wellcome Open Research","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"UCB Pharma; Horizon 2020; Sixth Framework Programme; Biotechnology and Biological Sciences Research Council; Medical Research Council; Abbott Diagnostics; Faculty of Medicine and Health, University of Sydney; U.S. Public Health Service; Servicio Andaluz de Salud; Diabetestutkimussäätiö; Canton de Genève; Tays; Comissió Interdepartamental de Recerca i Innovació Tecnològica; Chinese Society of Clinical Oncology; Novo Nordisk Fonden; Paavo Nurmen Säätiö; Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München; Diabetesliitto; Sociedad Española de Neumología y Cirugía Torácica; Deutsche Forschungsgemeinschaft; Ministry of Science and Technology, Croatia; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; Sydäntutkimussäätiö; Helsingin Yliopisto; SUVA; National Research Centre; Emil Aaltosen Säätiö; Directorate for Biological Sciences; Helse Midt-Norge; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Novo Nordisk; Research Councils UK; Juho Vainion Säätiö; National Health and Medical Research Council; UBS Optimus Foundation; Suomen Kulttuurirahasto; British Heart Foundation; Bundesministerium für Bildung und Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Tampereen Tuberkuloosisäätiö; Helmholtz Zentrum München; Kela; Raine Medical Research Foundation; University of Bristol; National Science Foundation; British Lung Foundation; Norwegian Institute of Public Health; Scottish Funding Council; Repubblica e Cantone Ticino; Asthma and Lung UK; Eesti Teadusfondi; Wellcome Trust; Cancer Research UK; National Institutes of Health; Stiftelsen Kristian Gerhard Jebsen; UK Research and Innovation; Chief Scientist Office; European Research Council; Academy of Finland; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Suomen Lääketieteen Säätiö; European Chiropractors' Union; Sanofi; Wellcome; Norges Teknisk-Naturvitenskapelige Universitet; Office Fédéral de l'Education et de la Science; Royal Society; European Commission; Ludwig-Maximilians-Universität München; National Institute for Health and Care Research; Yrjö Jahnssonin Säätiö; Freiwillige Akademische Gesellschaft; Age UK; Foundation for Cardiovascular Research","keywords":"Lung function; Function (biology); Expression (computer science); Lung; Differential (mechanical device); Differential effects; Cancer research; Biology; Genetics; Computational biology; Medicine; Internal medicine; Computer science; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005687659,0.0003434691,0.0003447551,0.0003941752,0.0003156439,0.0006257786,0.0003327673,0.0006093096,0.01084402],"category_scores_gemma":[0.002149917,0.0002021427,0.0008582866,0.0006699249,0.0004146885,0.0002238458,0.0004481455,0.0006244399,0.0008331128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997986,"about_ca_system_score_gemma":0.0001699199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003133872,"about_ca_topic_score_gemma":0.003068931,"domain_scores_codex":[0.999471,0.0001221405,0.00006397589,0.0001816876,0.00006851982,0.00009266613],"domain_scores_gemma":[0.9983817,0.0008013524,0.0005017644,0.0001454549,0.00007221063,0.00009738571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003650786,0.00004774636,0.9455404,0.0002889798,0.001310837,0.001551701,0.0003152032,0.0004332293,0.02408539,0.0005629607,0.004715688,0.01749709],"study_design_scores_gemma":[0.00008130212,0.0001142851,0.9924592,0.00005498496,0.0003376648,0.001448513,0.000103069,0.0003317916,0.002129603,0.0005765904,0.002345966,0.00001706104],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856673,0.001753159,0.0009279795,0.0007084688,0.00008698764,0.00001684853,0.008201048,0.00005089413,0.002587521],"genre_scores_gemma":[0.9954721,0.0004021945,0.0004895534,0.0002603036,0.0000632533,0.00002659841,0.002243391,0.00003834264,0.001004276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01084402,"threshold_uncertainty_score":0.03627688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09745985555252469,"score_gpt":0.3848638341925467,"score_spread":0.287403978640022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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