{"id":"W3208152686","doi":"10.12688/wellcomeopenres.15846.1","title":"Variants associated with HHIP expression have sex-differential effects on lung function","year":2020,"lang":"en","type":"preprint","venue":"Wellcome Open Research","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"UCB Pharma; Horizon 2020; Sixth Framework Programme; Biotechnology and Biological Sciences Research Council; Medical Research Council; Abbott Diagnostics; Faculty of Medicine and Health, University of Sydney; U.S. Public Health Service; Servicio Andaluz de Salud; Diabetestutkimussäätiö; Canton de Genève; Tays; Comissió Interdepartamental de Recerca i Innovació Tecnològica; Chinese Society of Clinical Oncology; Novo Nordisk Fonden; Paavo Nurmen Säätiö; Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München; Diabetesliitto; Sociedad Española de Neumología y Cirugía Torácica; Deutsche Forschungsgemeinschaft; Ministry of Science and Technology, Croatia; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; Sydäntutkimussäätiö; Helsingin Yliopisto; SUVA; National Research Centre; Emil Aaltosen Säätiö; Directorate for Biological Sciences; Helse Midt-Norge; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Novo Nordisk; Research Councils UK; Juho Vainion Säätiö; National Health and Medical Research Council; UBS Optimus Foundation; Suomen Kulttuurirahasto; British Heart Foundation; Bundesministerium für Bildung und Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Tampereen Tuberkuloosisäätiö; Helmholtz Zentrum München; Kela; Raine Medical Research Foundation; University of Bristol; National Science Foundation; British Lung Foundation; Norwegian Institute of Public Health; Scottish Funding Council; Repubblica e Cantone Ticino; Asthma and Lung UK; Eesti Teadusfondi; Wellcome Trust; Cancer Research UK; National Institutes of Health; Stiftelsen Kristian Gerhard Jebsen; UK Research and Innovation; Chief Scientist Office; European Research Council; Academy of Finland; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Suomen Lääketieteen Säätiö; European Chiropractors' Union; Sanofi; Wellcome; Norges Teknisk-Naturvitenskapelige Universitet; Office Fédéral de l'Education et de la Science; Royal Society; European Commission; Ludwig-Maximilians-Universität München; National Institute for Health and Care Research; Yrjö Jahnssonin Säätiö; Freiwillige Akademische Gesellschaft; Age UK; Foundation for Cardiovascular Research","keywords":"Lung function; Function (biology); Expression (computer science); Lung; Differential (mechanical device); Differential effects; Cancer research; Biology; Genetics; Computational biology; Medicine; Internal medicine; Computer science; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009410797,0.0005001632,0.0009817164,0.000406714,0.0004752492,0.000506737,0.0009593522,0.0006373851,0.001208787],"category_scores_gemma":[0.0007448161,0.0003525574,0.000195266,0.0003556836,0.0001709125,0.0001078571,0.002689491,0.003152705,0.0002983487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000405755,"about_ca_system_score_gemma":0.0009769974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000132199,"about_ca_topic_score_gemma":0.0000126708,"domain_scores_codex":[0.9935764,0.00160742,0.0004091256,0.001409029,0.002195394,0.0008026099],"domain_scores_gemma":[0.9968323,0.0006606866,0.0002052731,0.001095979,0.000402032,0.0008037447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.08079801,0.01070132,0.1718207,0.01518203,0.005268913,0.0122022,0.003030499,0.0004261159,0.1692917,0.0005723559,0.4283687,0.1023374],"study_design_scores_gemma":[0.02531003,0.01427697,0.8149748,0.03469313,0.001258345,0.00002272437,0.0007933123,0.01002072,0.07987974,0.001920089,0.0145013,0.002348835],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9381042,0.0003804655,0.0004857904,0.001680792,0.000702837,0.008912012,0.0001557853,0.0002290063,0.04934915],"genre_scores_gemma":[0.9844561,0.00003498836,0.00004198392,0.0003794215,0.0008252602,0.0005606521,0.0007487393,0.0001339318,0.01281889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6431541,"threshold_uncertainty_score":0.9998927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09745985555252469,"score_gpt":0.3848638341925467,"score_spread":0.287403978640022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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