{"id":"W3208190849","doi":"10.1002/ana.26260","title":"Natural History of Leigh Syndrome: A Study of Disease Burden and Progression","year":2021,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Newcastle University; National Institute for Health and Care Research; Medical Research Council Canada; Wellcome Trust","keywords":"Natural history; Leigh disease; Disease; Medicine; Psychiatry; Psychology; Pathology; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001176328,0.0003189043,0.0003467627,0.0006974546,0.0005489191,0.000616879,0.0004661424,0.000445231,0.0009778319],"category_scores_gemma":[0.003492178,0.0003541682,0.000450788,0.0008552453,0.000261138,0.0007640003,0.0008151294,0.0006724781,0.0002155787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003695583,"about_ca_system_score_gemma":0.0004187845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009680533,"about_ca_topic_score_gemma":0.006125535,"domain_scores_codex":[0.9993533,0.0002048542,0.00005867548,0.0001815539,0.0001084483,0.00009307679],"domain_scores_gemma":[0.9975189,0.0003108864,0.001393564,0.0002857973,0.0001764929,0.0003144034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000123088,0.00002041546,0.9989346,0.000004141712,0.00004477235,0.00003966633,0.00006249246,0.00002801467,0.0001034042,0.00001466148,0.00005209975,0.0005726037],"study_design_scores_gemma":[0.0000117885,0.00008955949,0.9991714,0.000006145623,0.00001597718,0.0002274618,0.0001094099,0.0001875795,0.0000256116,0.00002242693,0.0001288479,0.000003774549],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985002,0.000171218,0.0001928115,0.00003292346,0.000004250496,0.00001984809,0.0008035544,0.000006176867,0.0002688879],"genre_scores_gemma":[0.9983076,0.0001070355,0.0002251399,0.0000187714,0.000009959695,0.0000324106,0.001108731,0.000003707273,0.0001865703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009680533,"threshold_uncertainty_score":0.01924837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02954049506514891,"score_gpt":0.2958226096575803,"score_spread":0.2662821145924314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}