{"id":"W3208200442","doi":"10.1084/jem.20211872","title":"<i>Dnmt3a</i> -mutated clonal hematopoiesis promotes osteoporosis","year":2021,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Lady Davis Institute for Medical Research; National Heart, Lung, and Blood Institute; Brigham Research Institute; National Institutes of Health; Fondation de l'Hôpital général juif; Jewish General Hospital; Knut och Alice Wallenbergs Stiftelse; American Society of Hematology; Cancer Research UK; McGill University; Public Health Agency of Canada; Fondation Leducq; Edward P. Evans Foundation; Canadian Institutes of Health Research; Damon Runyon Cancer Research Foundation; Compute Canada; Deutsche Forschungsgemeinschaft; Burroughs Wellcome Fund; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; Howard Hughes Medical Institute","keywords":"Proinflammatory cytokine; Bone marrow; Haematopoiesis; Cancer research; Osteoporosis; Skeletal disorder; Somatic cell; Inflammation; Biology; Immunology; Cell biology; Genetics; Stem cell; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001125067,0.0002222795,0.0006708968,0.0001472476,0.0001410301,0.00001351381,0.000287584,0.00008394882,0.00223077],"category_scores_gemma":[0.0006192865,0.0001210362,0.0001621382,0.0005280545,0.0004759454,0.0001304188,0.0001444711,0.0006545426,0.0000394397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003440725,"about_ca_system_score_gemma":0.0005033434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004429344,"about_ca_topic_score_gemma":0.000001981527,"domain_scores_codex":[0.9973156,0.0002381214,0.0007693845,0.0001610199,0.001156093,0.0003597673],"domain_scores_gemma":[0.9979659,0.0003872336,0.0003269209,0.0003928181,0.0005705862,0.0003565593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009957351,0.0003455117,0.0004422042,0.00004744215,0.0002830851,0.001125991,0.00424721,0.000001247816,0.9647163,0.00007864055,0.02716738,0.0005493117],"study_design_scores_gemma":[0.005473571,0.002132901,0.0008130177,0.0005819452,0.0002798643,0.01705076,0.01638484,0.00005082009,0.9538081,0.0001087945,0.003198752,0.0001166382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949988,0.01785537,0.00006078847,0.02704668,0.0003783666,0.0002686776,0.000003295235,0.00002345724,0.004375347],"genre_scores_gemma":[0.9934353,0.0005068839,0.001163648,0.002528583,0.0009253179,0.000005650466,0.00001269599,0.00004113291,0.00138077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0434473,"threshold_uncertainty_score":0.9986813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02739880157359871,"score_gpt":0.3318098689552111,"score_spread":0.3044110673816124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}