{"id":"W3208200442","doi":"10.1084/jem.20211872","title":"<i>Dnmt3a</i> -mutated clonal hematopoiesis promotes osteoporosis","year":2021,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Lady Davis Institute for Medical Research; National Heart, Lung, and Blood Institute; Brigham Research Institute; National Institutes of Health; Fondation de l'Hôpital général juif; Jewish General Hospital; Knut och Alice Wallenbergs Stiftelse; American Society of Hematology; Cancer Research UK; McGill University; Public Health Agency of Canada; Fondation Leducq; Edward P. Evans Foundation; Canadian Institutes of Health Research; Damon Runyon Cancer Research Foundation; Compute Canada; Deutsche Forschungsgemeinschaft; Burroughs Wellcome Fund; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; Howard Hughes Medical Institute","keywords":"Proinflammatory cytokine; Bone marrow; Haematopoiesis; Cancer research; Osteoporosis; Skeletal disorder; Somatic cell; Inflammation; Biology; Immunology; Cell biology; Genetics; Stem cell; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706818,0.0002008038,0.0002015252,0.0002696935,0.0001248904,0.0002881901,0.0001131935,0.0002427618,0.003387574],"category_scores_gemma":[0.0001814823,0.0001076037,0.0002001035,0.000155081,0.0002482945,0.00009604744,0.0001928037,0.0004961452,0.0004018069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002309467,"about_ca_system_score_gemma":0.0001867242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006093264,"about_ca_topic_score_gemma":0.001047653,"domain_scores_codex":[0.9998722,0.00002352493,0.00001028897,0.00002706866,0.00003703032,0.00002981719],"domain_scores_gemma":[0.9998833,0.00001760852,0.00004255168,0.00001341504,0.000009658081,0.00003342061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003372944,0.00004755315,0.002992918,0.00005394148,0.00002134256,0.0001712467,0.00001187642,0.00007384897,0.990422,0.0002928358,0.0003281689,0.005246936],"study_design_scores_gemma":[0.0001412061,0.000810465,0.1202067,0.00004968309,0.0001265979,0.004960224,0.00008178743,0.002189132,0.8551231,0.0007967882,0.01549944,0.00001490022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913025,0.001903577,0.002076451,0.0004879556,0.00004443367,0.00003008179,0.0009608242,0.0002567704,0.002937381],"genre_scores_gemma":[0.9974152,0.0004951532,0.0006466483,0.0001078138,0.00001526991,0.000009830941,0.0002449793,0.00001611314,0.001049065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003387574,"threshold_uncertainty_score":0.01133257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02739880157359871,"score_gpt":0.3318098689552111,"score_spread":0.3044110673816124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}