{"id":"W3208204329","doi":"10.1016/s1470-2045(21)00531-3","title":"Maintenance olaparib for patients with newly diagnosed advanced ovarian cancer and a BRCA mutation (SOLO1/GOG 3004): 5-year follow-up of a randomised, double-blind, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":371,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Merck Sharp and Dohme; AstraZeneca","keywords":"Olaparib; Ovarian cancer; Mutation; BRCA mutation; Clinical trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002066207,0.001646015,0.003701641,0.0004210163,0.0004827471,0.001298916,0.001041427,0.002004996,0.00463624],"category_scores_gemma":[0.001743863,0.0006294756,0.002743182,0.0004785932,0.001240505,0.001489094,0.0004747766,0.003347686,0.0009892314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008135705,"about_ca_system_score_gemma":0.0008681882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000418,"about_ca_topic_score_gemma":0.001918931,"domain_scores_codex":[0.9992921,0.0003454009,0.00003654573,0.0001455779,0.00005088628,0.0001294349],"domain_scores_gemma":[0.9987789,0.0003199797,0.0003047273,0.0001331179,0.00005933442,0.0004040481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9826201,0.001748991,0.0007624234,0.0003056918,0.0009559313,0.00003183231,0.0000334848,0.0002491619,0.001229576,0.00004432932,0.0004879801,0.01153036],"study_design_scores_gemma":[0.9501166,0.04422098,0.003700906,0.00003454239,0.0005910416,0.00004738449,0.00002181101,0.0003339581,0.0002194901,0.0001613604,0.0005344499,0.00001749844],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842601,0.00923807,0.0006554594,0.0007589425,0.0004529094,0.001353387,0.001420966,0.0001443981,0.001715793],"genre_scores_gemma":[0.9886006,0.003366562,0.0007999042,0.001141348,0.0003764794,0.001380453,0.001989464,0.00002610756,0.002319107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00463624,"threshold_uncertainty_score":0.01550972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04020537618833177,"score_gpt":0.3627496910676291,"score_spread":0.3225443148792974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}