{"id":"W3208208486","doi":"10.3390/toxins13110763","title":"Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines","year":2021,"lang":"en","type":"article","venue":"Toxins","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bordetella pertussis; Toxin; Pertussis toxin; Bordetella; Microbiology; Cyclase; Adenylate kinase; Pertactin; Adenylate Cyclase Toxin; Chemistry; Biology; Bacteria; Biochemistry; Enzyme; G protein; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008099519,0.0004195567,0.0009224368,0.0003296084,0.0002406445,0.00004827403,0.0001966524,0.000501568,0.0006178],"category_scores_gemma":[0.0007323912,0.0003887683,0.000178809,0.0004415288,0.0001117075,0.0001837597,0.0001272911,0.0003718596,0.0000276625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007921629,"about_ca_system_score_gemma":0.0002344079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005363141,"about_ca_topic_score_gemma":0.001924,"domain_scores_codex":[0.9970058,0.0007461202,0.0008635788,0.0007060555,0.00004365993,0.0006347358],"domain_scores_gemma":[0.9974509,0.001570995,0.0002575515,0.0004208035,0.0002243118,0.00007537834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00113281,0.0005407859,0.001133407,0.000111903,0.0002861556,0.00001928198,0.00167195,0.0001532808,0.9881761,0.001032683,0.0009547226,0.004786897],"study_design_scores_gemma":[0.006753757,0.001556295,0.02410443,0.000165017,0.0002759881,0.00043601,0.001522548,0.001086422,0.9583707,0.001030736,0.003954586,0.0007435558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757342,0.003600706,0.01778498,0.0008534297,0.0004924634,0.001024062,0.000221027,0.00008184644,0.0002073124],"genre_scores_gemma":[0.9679433,0.0004837596,0.02947448,0.000156061,0.000084201,0.0002140067,0.0001388247,0.00006994718,0.00143544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02980547,"threshold_uncertainty_score":0.9998564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03700216413932985,"score_gpt":0.3124044924434151,"score_spread":0.2754023283040852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}