{"id":"W3208208486","doi":"10.3390/toxins13110763","title":"Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines","year":2021,"lang":"en","type":"article","venue":"Toxins","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bordetella pertussis; Toxin; Pertussis toxin; Bordetella; Microbiology; Cyclase; Adenylate kinase; Pertactin; Adenylate Cyclase Toxin; Chemistry; Biology; Bacteria; Biochemistry; Enzyme; G protein; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002907489,0.001237888,0.0008763711,0.001206874,0.0009534663,0.001017849,0.00129324,0.001880783,0.001421605],"category_scores_gemma":[0.002446481,0.00111357,0.0005971825,0.0006056929,0.0008512877,0.0007660547,0.0006294073,0.001457715,0.001659698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001330683,"about_ca_system_score_gemma":0.003003036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001480693,"about_ca_topic_score_gemma":0.002726886,"domain_scores_codex":[0.9967018,0.0006074084,0.0001886227,0.0009997474,0.001321836,0.000180511],"domain_scores_gemma":[0.9987966,0.0003917245,0.0001855027,0.0000902525,0.0004104572,0.0001254483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001285925,0.00009530193,0.0006907858,0.0001232554,0.0000210257,0.00003372169,0.00003672697,0.0004473318,0.9888151,0.0003302846,0.0002300489,0.009047884],"study_design_scores_gemma":[0.00005055918,0.0005684624,0.001761603,0.00002542037,0.00004130221,0.0002901901,0.00004005068,0.02170691,0.9694878,0.0002924092,0.005682293,0.00005303333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1880008,0.002208503,0.7961019,0.0007478863,0.0003565727,0.003457909,0.001600198,0.004556036,0.002970177],"genre_scores_gemma":[0.1914426,0.0009894536,0.7968288,0.0009307475,0.0001081603,0.003063023,0.001180189,0.000310742,0.005146349],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002907489,"threshold_uncertainty_score":0.01537645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03700216413932985,"score_gpt":0.3124044924434151,"score_spread":0.2754023283040852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}