{"id":"W3208255601","doi":"10.1523/eneuro.0350-21.2021","title":"Knock-Down of Heterogeneous Nuclear Ribonucleoprotein A1 Results in Neurite Damage, Altered Stress Granule Biology, and Cellular Toxicity in Differentiated Neuronal Cells","year":2021,"lang":"en","type":"article","venue":"eNeuro","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Cameco (Canada)","funders":"Saskatchewan Cancer Agency; University of Saskatchewan","keywords":"Heterogeneous nuclear ribonucleoprotein; Neurite; Stress granule; Ribonucleoprotein; Cell biology; Biology; RNA; RNA-binding protein; Neurodegeneration; Heterogeneous ribonucleoprotein particle; Gene; Genetics; Messenger RNA; In vitro; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051291,0.000373987,0.0003526497,0.0001781111,0.0001821046,0.0003014987,0.0001969888,0.0002482907,0.0009760067],"category_scores_gemma":[0.00007519799,0.0001148702,0.0003526788,0.000184476,0.000216433,0.0001604714,0.0002223519,0.0005695161,0.0004502278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773334,"about_ca_system_score_gemma":0.0002388046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001357731,"about_ca_topic_score_gemma":0.002046129,"domain_scores_codex":[0.9998683,0.000009278428,0.00002092737,0.00004038299,0.00004009097,0.00002097891],"domain_scores_gemma":[0.9998909,0.00001810897,0.00003377736,0.00001337751,0.00001361005,0.00003029444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003299561,0.00001192749,0.00008977858,0.00002438435,0.000005422894,0.000051394,0.00001170707,0.00005502887,0.9991505,0.00003517051,0.000018854,0.0005128362],"study_design_scores_gemma":[0.000007322399,0.0001225686,0.005336836,0.000007492964,0.00002397236,0.0001567859,0.00003832808,0.001074081,0.9916381,0.00005236599,0.001537443,0.000004625676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903917,0.001161968,0.004785904,0.0000949606,0.00004701195,0.00003021232,0.001562964,0.0001750972,0.001750207],"genre_scores_gemma":[0.9826158,0.001635877,0.006887951,0.00009557758,0.000007452379,0.00007987222,0.002237922,0.00007655714,0.006362916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357731,"threshold_uncertainty_score":0.003265023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009845410773576847,"score_gpt":0.2460056436819144,"score_spread":0.2361602329083376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}