{"id":"W3208255601","doi":"10.1523/eneuro.0350-21.2021","title":"Knock-Down of Heterogeneous Nuclear Ribonucleoprotein A1 Results in Neurite Damage, Altered Stress Granule Biology, and Cellular Toxicity in Differentiated Neuronal Cells","year":2021,"lang":"en","type":"article","venue":"eNeuro","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Cameco (Canada)","funders":"Saskatchewan Cancer Agency; University of Saskatchewan","keywords":"Heterogeneous nuclear ribonucleoprotein; Neurite; Stress granule; Ribonucleoprotein; Cell biology; Biology; RNA; RNA-binding protein; Neurodegeneration; Heterogeneous ribonucleoprotein particle; Gene; Genetics; Messenger RNA; In vitro; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409058,0.0001726044,0.0002427546,0.00009780269,0.00004050168,0.00002559509,0.0001926022,0.0001363722,0.00001798606],"category_scores_gemma":[0.0001541097,0.0001771513,0.00006503607,0.0001634705,0.0001085961,0.000005421553,0.000316899,0.0002254174,0.000001988311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007588266,"about_ca_system_score_gemma":0.00003535541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002155166,"about_ca_topic_score_gemma":0.0005958898,"domain_scores_codex":[0.998275,0.0003426413,0.0003563123,0.0005462915,0.0001151111,0.0003645822],"domain_scores_gemma":[0.9993438,0.00003349725,0.00007917664,0.000385487,0.00004930171,0.0001087764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002374031,0.0001824256,0.00627033,0.00003917525,0.00001107249,0.0001321426,0.00002866766,0.0001991657,0.9922618,0.000009336401,0.00004283066,0.0005857024],"study_design_scores_gemma":[0.001393619,0.0002920254,0.0321589,0.00003001317,0.000003759732,0.000008566568,0.00001484215,0.00113115,0.9643142,0.00002885679,0.0004767209,0.0001473734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990595,0.0002927907,0.00001348494,0.0001170975,0.00007686574,0.0001742532,0.0001719942,0.000007732431,0.00008625548],"genre_scores_gemma":[0.9991417,0.0002563217,0.00007157801,0.0001116502,0.000046945,0.000005452639,0.000164802,0.00002593678,0.0001755925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02794758,"threshold_uncertainty_score":0.7224022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009845410773576847,"score_gpt":0.2460056436819144,"score_spread":0.2361602329083376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}