{"id":"W3208310157","doi":"10.1097/pr9.0000000000000960","title":"Epigenetic signature of chronic low back pain in human T cells","year":2021,"lang":"en","type":"article","venue":"PAIN Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital; Montreal Clinical Research Institute; McGill University","funders":"Réseau québécois de recherche sur la douleur; Louise and Alan Edwards Foundation; Institut de Recherche Clinique De Montréal","keywords":"DNA methylation; Epigenetics; Chronic pain; Signature (topology); Low back pain; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338912,0.00009932098,0.000145569,0.0003100425,0.000116954,0.0002275125,0.00007963936,0.0001496204,0.001260403],"category_scores_gemma":[0.0004280542,0.0000839199,0.00009130983,0.0002900411,0.0001130206,0.00007070666,0.0001489857,0.0001157192,0.0002001344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009157561,"about_ca_system_score_gemma":0.0001127472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009390282,"about_ca_topic_score_gemma":0.001122541,"domain_scores_codex":[0.9998984,0.00001728395,0.000006055387,0.00003461024,0.00002519147,0.00001849026],"domain_scores_gemma":[0.9998648,0.00002529399,0.00005698208,0.00001333892,0.00002544269,0.00001416961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007519839,0.00005292091,0.2630882,0.0001132219,0.000104837,0.0002582471,0.0003185795,0.0002254825,0.7165426,0.0001181446,0.0002212007,0.01820453],"study_design_scores_gemma":[0.00002213867,0.0003633489,0.9623308,0.00001122677,0.00005202159,0.0008771241,0.0001409247,0.0005519608,0.03466644,0.0001340408,0.0008436089,0.000006300002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977204,0.0005571729,0.0007437911,0.00002790728,0.000003909016,0.000009265917,0.0005237945,0.00001077273,0.0004028706],"genre_scores_gemma":[0.9988039,0.0001703304,0.0002600497,0.00002337617,0.000004994804,0.0000116517,0.0003432865,0.000002387039,0.0003800206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001260403,"threshold_uncertainty_score":0.004216433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006366200578847174,"score_gpt":0.2404696962618164,"score_spread":0.2341034956829692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}